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Involvement of histamine H1 and H2 receptors in hypothermia induced by ionizing radiation in guinea pigs

Journal Article · · Life Sci.; (United States)
;

Radiation-induced hypothermia was examined in guinea pigs. Exposure to the head alone or whole-body irradiation induced hypothermia, whereas exposure of the body alone produced a small insignificant response. Systemic injection of disodium cromoglycate (a mast cell stabilizer) and cimetidine (H2-receptor antagonist) had no effect on radiation-induced hypothermia, whereas systemic and central administration of mepyramine (H1-receptor antagonist) or central administration of disodium cromoglycate or cimetidine attenuated it, indicating the involvement of central histamine through both H1 and H2 receptors in this response. Serotonin is not involved, since the serotonin antagonist methysergide had no effect on radiation-induced hypothermia. These results indicate that central histaminergic systems may be involved in radiation-induced hypothermia. 34 references, 5 figures, 2 tables.

Research Organization:
Armed Forces Radiobiology Research Institute, Bethesda, MD
OSTI ID:
5650210
Journal Information:
Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:5; ISSN LIFSA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
DATA
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FUNCTIONS
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYPOTHERMIA
IMIDAZOLES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEMBRANE PROTEINS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARTIAL BODY IRRADIATION
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECEPTORS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION