Effect of caffeine on induction of endogenous type C virus in mouse cells in vitro
The effect of caffeine on the expression of murine endogenous virus in mouse cells induced by radiation and chemicals was studied. Postirradiation treatment of K-BALB cells with caffeine enhanced cell killing as well as the induction of xenotropic virus after ultraviolet light irradiation. The degree of enhancement for the virus induction was comparable to that for cell killing. On the other hand, colony-forming ability and the expression of xenotropic virus of K-BALB cells after X-irradiation were unaffected by caffeine. These data suggest a linear relationship between the degree of endogenous virus expression and the amount of lethal damages after irradiation. For induction by halogenated pyrimidines, a 24-hr incubation of AKR2B cells with caffeine after 5-iodo-2'-deoxyuridine treatment resulted in marked suppression of the expression of ecotropic virus. On the contrary, in K-BALB cells, caffeine exerted only a small effect on 5-iodo-2'-deoxyuridine-induced expression of ecotropic and xenotropic viruses. These results indicate that, although using the same inducing agent, the pathway of endogenous virus induction may be different for AKR2B cells and for K-BALB cells.
- OSTI ID:
- 5637093
- Journal Information:
- Cancer Res.; (United States), Vol. 41:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CAFFEINE
RADIOSENSITIVITY EFFECTS
CELL KILLING
RADIOINDUCTION
ONCOGENIC TRANSFORMATIONS
DOSE-RESPONSE RELATIONSHIPS
IN VITRO
IODODEOXYURIDINE
MICE
ULTRAVIOLET RADIATION
VIRUSES
X RADIATION
ANALEPTICS
ANIMALS
ANTIMETABOLITES
AZINES
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IODOURACILS
IONIZING RADIATIONS
MAMMALS
MICROORGANISMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PARASITES
PURINES
PYRIMIDINES
RADIATIONS
RIBOSIDES
RODENTS
URACILS
VERTEBRATES
XANTHINES
560121* - Radiation Effects on Cells- External Source- (-1987)