Radiation induction of endogenous type C virus from mouse cells transformed in vitro by murine sarcoma virus

Journal Article · Thu Feb 01 04:00:00 EST 1979 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6530240

Cell lines from AKR and BALB/c mouse embryos were compared for their sensitivity to x-ray induction of endogenous type C virus. K-Balb cells, a Balb/3T3 cell line nonproductively transformed by Kirsten murine sarcoma virus, were found to be sensitive to x-irradiation. At a dose as low as 50 R, x rays induced virus expression in K-Balb cells, and the induction frequency increased with increasing dose of x rays up to 400 R. Among two classes of inducible endogenous viruses carried by K-Balb cells, only Balb:virus-2 was activated by x irradiation, whereas both Balb:virus-1 and Balb:virus-2 were activated after the cells were treated with 5-iodo-2'-deoxyuridine. uv light and 4-nitroquinoline 1-oxide were also shown to induce virus expression in K-Balb cells. The virus-induction frequency for these physical and chemical carcinogens was much lower (approx. = 3 x 10/sup -4/) than that for 5-bromo-2'-deoxyuridine (approx. = 1 x 10/sup -1/).

• Research Organization: Kyoto Univ., Japan
• OSTI ID: 6530240
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 62:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BROMOURACILS
BUDR
CARCINOGENS
CELL CULTURES
DRUGS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IODODEOXYURIDINE
IODOURACILS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
NUCLEOSIDES
NUCLEOTIDES
ONCOGENIC VIRUSES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOACTIVATION
RIBOSIDES
RODENTS
ULTRAVIOLET RADIATION
URACILS
VERTEBRATES
VIRUSES
X RADIATION