Visualization of metastases from colon carcinoma using an iodine 131-radiolabeled monoclonal antibody

Journal Article · Sat Mar 15 00:00:00 EST 1986 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19860315)57:6<1135::AID-CNCR2820570613>3.0.CO;2-3· OSTI ID:5636468

Leyden, M J; Thompson, C H; Lichtenstein, M; Andrews, J T; Sullivan, J R; Zalcberg, J R; McKenzie, I F

A murine monoclonal antibody that reacts with human colonic cancer (250-30.6) was labeled with radioactive iodine (131I) and the antibody was injected intravenously into 15 patients with known metastases originating from carcinoma of the colon (10 cases), malignant melanoma (1), breast (1), pancreas (1), hepatocellular carcinoma (1), and adenocarcinoma of unknown origin (1). Of the patients with metastatic colon carcinoma, there were 19 known deposits as judged by the techniques of clinical examination, x-rays, and scans obtained using sulpha-colloid. Of these 19 deposits, 17 (90%) were found using the 131I-labeled monoclonal antibody. In one case, the primary tumor, previously undiagnosed, was found. In only 1 of the 10 patients was tumor not found and this was due to the subsequent finding that the undifferentiated tumor did not react with antibody. Of the five patients who did not have carcinoma of the colon, three had negative scans, but two were positive. Thus, the technique of immunoscintography can readily detect both primary and metastatic tumors.

• Research Organization: Royal Melbourne Hospital, Victoria, Australia
• OSTI ID: 5636468
• Journal Information: Cancer (Philadelphia); (United States), Vol. 6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
METASTASES
DIAGNOSIS
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
ADENOMAS
CARCINOMAS
IODINE 131
LABELLED COMPOUNDS
LARGE INTESTINE
LIVER
MAMMARY GLANDS
MELANOMAS
PANCREAS
PATIENTS
SCINTISCANNING
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics