Radiolocalization of colon cancer with I-131 B72. 3 monoclonal antibody

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6856576

Carrasquillo, J A; Colcher, D; Sugarbaker, P; Reynolds, J R; Keenan, A M; Simpson, D; Bryant, G; Thor, A; Perentesis, P; Esteban, J

I-131 labeled monoclonal antibody B72.3 (IgGl) which targets a tumor-associated antigen present in breast and 80% of colon carcinomas was utilized to image 19 patients (pts) with metastatic colon cancer. B72.3 was labeled via the iodogen method, and administered as a 1h infusion. Pts were studied at .27 mg (range .16-.46) and 1.3 mCi (11 pts), 3.8 mg (range 3.7-4) and 1.5 mcl (3 pts) and 1.19 mg (range 1.1-l.4) and 9 mCi (5 pts) in order to asses the effect of B72.3 dose(mg) on biodistribution as well as the effect of improved counting statistics on the scintigrams. 10 of 19 patients had positive scans. In this limited study no dose related effect on tumor uptake was found. Optimal images were obtained at 7 days when background levels had dropped. The scans showed no concentration in normal organs. The blood pool clearance was prolonged with a mean T 1/2 of 31-52h and not significantly different for the various dose levels. The total body clearance determined by NaI crystal probe counts was approximately 3-4 days for all groups. The route of excretion was predominantly renal. No toxicity was observed. An antimouse immune response was seen in 5 of 16 patients tested. This data indicate the feasibility of targetting colon cancer B72.3. The prolonged retention in the blood pool requiring delayed images for optimal target to non target ratios and the high levels of antimouse immune response suggest that the use of Fab or F(ab')/sub 2/ should be explored.

• Research Organization: Div. of Tumor Immunology and Biology, Surgery Branch, Lab. of Pathology, NCI, Bethesda, MD
• OSTI ID: 6856576
• Report Number(s): CONF-850611-
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
655003 -- Medical Physics-- Dosimetry
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARCINOEMBRYONIC ANTIGEN
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSIMETRY
DRUGS
EXCRETION
FUNCTIONS
GASTROINTESTINAL TRACT
IMAGES
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLED POOL TECHNIQUES
LABELLING
LARGE INTESTINE
MEASURING INSTRUMENTS
MEDICINE
MONOCLONAL ANTIBODIES
NAI DETECTORS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OPTIMIZATION
ORGANS
PATIENTS
RADIATION DETECTORS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RETENTION FUNCTIONS
SCINTILLATION COUNTERS
SCINTISCANNING
SOLID SCINTILLATION DETECTORS
THERAPY
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE