Pure erythrocytosis: reappraisal of a study of 51 cases

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Am. J. Hematol.; (United States)

DOI:https://doi.org/10.1002/ajh.2830100204· OSTI ID:5577833

Najean, Y; Triebel, F; Dresch, C

Fifty-one cases of pure, primary erythrocytosis were identified and followed at Hopital Saint-Louis, Paris, and compared with 350 cases of polycythemia vera (PV) observed during the same period. At the initial evaluation, these cases did not differ from PV cases with respect to age, sex ratio, degree of red cell volume increase, and clinical symptoms. They did differ by the absence of splenomegaly, granulocytosis and thrombocytosis. At a late stage of evolution only a few cases developed classical criteria of PV. From this group of apparently homogeneous cases, two subgroups evolved. Sixty percent of the cases were highly responsive to myelosuppression with /sup 32/P. The median duration of the first remission was greater than five years, the mean yearly dose of /sup 32/P was very low, and there was a low incidence of complications. The other group (40% of cases) was relatively resistant to myelosuppressive agents. The development of better methods of investigate this disorder might help in discriminating these two groups from both an etiological and pathophysiological viewpoint. The thromboembolic risk of these diseases suggests that myelosuppressive therapy should be utilized in older patients with higher risk of vascular accidents, reserving phlebotomy for younger patients and those who are shown to be resistant to /sup 32/P therapy.

• OSTI ID: 5577833
• Journal Information: Am. J. Hematol.; (United States), Vol. 10:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
PHOSPHORUS 32
RADIOTHERAPY
POLYCYTHEMIA
PATHOLOGY
AGE DEPENDENCE
DIAGNOSIS
ETIOLOGY
MYELOID LEUKEMIA
PATIENTS
RADIATION DOSES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
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HEMIC DISEASES
ISOTOPES
LEUKEMIA
LIGHT NUCLEI
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RADIOLOGY
THERAPY
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