Polycythaemia vera
Journal Article
·
· Deutsche Medizinische Wochenschrift
The effects of P32 injections in 132 patients with polycythemia vera are described. P32 was given intravenously in doses of 3 to 8 mc in 120 cases, and later orally in doses of 5 mc in some cases. An average of 5.5 mc was required to normalize red cell levels; the yearly dose averaged 4.4 mc per patient. In half of the patients the remissions lasted for 12 months or longer. Larger than average doses were required to treat patients with marked splenomegaly and (or) very high leukocyte counts, and patients with longlasting disease. No correlation was found between the P32 dose required to induce remission and other factors such as age, sex, and constitutional type. A given dose of P32 produced a greater fall in red cell count in patients with the highest initial count, and for patients with similar initial counts, the higher the dose the greater the fall in red cell level. 1n some cases, a correlation was found between the amount of P32 administered and duration of remission. Longer remissions were observed in patlents who showed the sharpest fall in counts after P32 was given. 1n 11% of the cases there was an unusually marked but reversible depression in hematopoiesis after P32. In the 8-yr follow-up period, 23 patients died, including 4 which developed acute myeloid leukemia, 2 chronic myeloid leukemia, and 3 osteomyelofibrosis.
- Research Organization:
- Universitat, Cologne
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-005687
- OSTI ID:
- 4751640
- Journal Information:
- Deutsche Medizinische Wochenschrift, Journal Name: Deutsche Medizinische Wochenschrift Journal Issue: 39 Vol. 86; ISSN 0012-0472
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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