Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update
The temporal and spatial distributions of {sup 238}Pu have been measured during the course of a dose-response study of the biological effects of inhaled {sup 238}PuO{sub 2} in Beagle dogs. These measurements were done on the dose-response study animals, as well as a separate group of dogs exposed to similar aerosols and killed serially out to 4 y after exposure. The data from this latter group provided the basis for the development of a biokinetic/dosimetric model for {sup 238}PuO{sub 2} in dogs. Since the publication of this model, several important findings have been made that affected the dosimetric evaluations. The first involved the discovery of significant quantities of natural uranium (U) in the feces samples. The U was measured with the plutonium (Pu), which inflated the values for purported Pu in feces. The second finding involved the addition of Pu biokinetics data from the dose-response dogs, which increased the period of observation from 4 y to 15 y; these later data were not consistent with the earlier model predictions. The purpose of this investigation was (1) to remove the analytical bias in the {sup 238}Pu radiochemical data due to the U and (2) to modify the original model of Mewhinney and Diel, taking into account all data from both studies.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 54831
- Report Number(s):
- ITRI-144; ON: DE95007526; TRN: 95:012773
- Resource Relation:
- Other Information: PBD: Nov 1994; Related Information: Is Part Of Inhalation Toxicology Research Institute annual report, October 1, 1993--September 30, 1994; Belinsky, S.A.; Hoover, M.D.; Bradley, P.L. [eds.]; PB: 211 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Primary bone neoplasms in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide
Hematological responses after inhaling {sup 238}PuO{sub 2}: An extrapolation from beagle dogs to humans