Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine

Journal Article · Mon May 01 00:00:00 EDT 1989 · Pigment Cell Research; (USA)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00182.x· OSTI ID:5479089

Mileo, A M; Mattei, E; Fanuele, M; Delpino, A; Ferrini, U ^[1]

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1. Regina Elena Cancer Institute, Rome (Italy)

The relationship between cell pigmentation and radiosensitivity was investigated in a cell model in which melanogenesis was suppressed by a glycosylation inhibitor. It was found that X-irradiation of melanotic B-16 melanoma cells and their amelanotic counterparts, obtained by glucosamine treatment, showed an inverse correlation between radiosensitivity and melanin contents. Since melanogenesis interruption by glucosamine does not affect the DNA repair capacity of nonpigmented cells, it is likely that intracellular melanins play a role in the relative resistance of pigmented cells to X-irradiation.

• OSTI ID: 5479089
• Journal Information: Pigment Cell Research; (USA), Vol. 2:3; ISSN 0893-5785
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MELANIN
RADIOSENSITIVITY EFFECTS
TUMOR CELLS
RADIOSENSITIVITY
DNA REPAIR
EXPERIMENTAL NEOPLASMS
GLUCOSAMINE
MELANOMAS
MICE
SURVIVAL TIME
X RADIATION
AMINES
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBOHYDRATES
DISEASES
ELECTROMAGNETIC RADIATION
HEXOSAMINES
HEXOSES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MONOSACCHARIDES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
SACCHARIDES
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture