Cerebral distribution of immunoconjugate after treatment for neoplastic meningitis using an intrathecal radiolabeled monoclonal antibody

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Neurosurgery; (USA)

DOI:https://doi.org/10.1227/00006123-198908000-00015· OSTI ID:5468371

Benjamin, J C; Moss, T; Moseley, R P; Maxwell, R; Coakham, H B ^[1]

---

1. Frenchay Hospital, Bristol (England)

A detailed autopsy and autoradiographic study was performed after the death of a patient undergoing intrathecal, antibody-guided irradiation for carcinomatous meningitis. The results demonstrated tumor cells infiltrating the surface meninges and a severe astrocytic reaction associated with oedema in the periventricular and brain stem subpial white matter. This was not seen in cortical or other gray matter structures. Autoradiographic examination correlated well, demonstrating isotope within the oedematous areas of the white matter in addition to the expected concentration in the leptomeningeal layers. These findings are discussed in the context of antibody binding to tumor tissue and the possible benefits conferred in the treatment of infiltrating tumor cells.

• OSTI ID: 5468371
• Journal Information: Neurosurgery; (USA), Vol. 25:2; ISSN 0148-396X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
CARCINOMAS
IMMUNOTHERAPY
RADIOIMMUNOTHERAPY
RADIOTHERAPY
MONOCLONAL ANTIBODIES
TISSUE DISTRIBUTION
AUTOPSY
AUTORADIOGRAPHY
DEATH
IODINE ISOTOPES
PATIENTS
TUMOR CELLS
ANIMAL CELLS
ANTIBODIES
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
IMMUNOLOGY
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIOIMMUNOLOGY
RADIOLOGY
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)