Organ specificity of aryl hydrocarbon hydroxylase induction by cigarette smoke
- Univ. of Occupational and Environmental Health, Fukuoka (Japan)
Biotransformation of many chemicals found in cigarette smoke, such as PAHs and nitrosamines, is generally considered essential for the mutagenic, carcinogenic effects of these xenobiotics. In fact, the genotic action of these premutagens or precarcinogens is dependent on metabolic activation catalyzed by microsomal monooxygenases. The first enzymatic reaction of the PAHs metabolic pathway is catalyzed by a cytochrome P-450-dependent monooxygenase, the aryl hydrocarbon hydroxylase (AHH). AHH leads to the formation of reactive arene oxides, which are further metabolized by enzymatic and non-enzymatic reaction into many metabolites. AHH induction in laboratory animals exposed to cigarette smoke has also been reported, and the data show that this response is highly dependent on species and tissues. Exposure of small laboratory animals to cigarette smoke generally induces AHH in the kidney and lung, while the effect of cigarette smoke on the hepatic AHH activity appears variable.
- OSTI ID:
- 5457946
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 44:6; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of single and repeated cigarette smoke-exposures on the activities of aryl hydrocarbon hydroxylase, epoxide hydratase and UDP glucuronosyltransferase in rat lung, kidney and small intestinal mucosa
Cadmium-enriched cigarette smoke-induced cytological and biochemical alterations in rat lungs
Related Subjects
ARYL 4-MONOOXYGENASE
ENZYME INDUCTION
TOBACCO SMOKES
INHALATION
ENZYME ACTIVITY
HYDROXYLASES
KIDNEYS
LIVER
LUNGS
METABOLIC ACTIVATION
RATS
AEROSOLS
ANIMALS
BODY
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYMES
GENE REGULATION
GLANDS
INTAKE
MAMMALS
ORGANS
OXIDOREDUCTASES
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology