Environmental carcinogens in human target tissues in culture. Progress report

Technical Report · Fri Oct 19 00:00:00 EDT 1984

OSTI ID:5444106

Hsu, I C

The metabolism and mutagenicity of 1-nitropyrene, 1-aminopyrene, 2-aminofluorene and acetylaminofluarene in hepatic cell cultures is investigated. Metabolic products were assayed by thin-layer chromatography. Ancillary studies on Ames' assary mutagencity screening, unscheduled DNA synthesis by hepatocytes and binding to nuclear structures are also reported. 1 fig., 1 tab.

• Research Organization: Maryland Univ., Baltimore (USA). School of Medicine
• DOE Contract Number: AS05-83ER60158
• OSTI ID: 5444106
• Report Number(s): DOE/ER/60158-1; ON: DE85017188
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ACETYLAMINOFLUORENES
MUTAGEN SCREENING
POLYCYCLIC AROMATIC AMINES
METABOLISM
POLYCYCLIC NITRO COMPOUNDS
AFLATOXIN
CELL CULTURES
ELECTRON MICROSCOPY
LIVER CELLS
MACROPHAGES
MEN
METABOLIC ACTIVATION
MICE
RATS
THIN-LAYER CHROMATOGRAPHY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMAL CELLS
ANIMALS
ANTIGENS
CHROMATOGRAPHY
CONNECTIVE TISSUE CELLS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MALES
MAMMALS
MAN
MATERIALS
MICROSCOPY
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PRIMATES
RODENTS
SCREENING
SEPARATION PROCESSES
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
550501 - Metabolism- Tracer Techniques