Dietary calcium and magnesium in the development of hypertension in the spontaneously hypertensive rat
The role of dietary calcium and magnesium in attenuation of hypertension was studied in 9 groups of 9 spontaneously hypertensive rats ages 8 to 31 weeks. The animals were fed AIN 76 semipurified diets altered in calcium (0.075%, 0.5%, and 2.5%) and magnesium (0.01%, 0.05%, and 0.75%) using a 3 x 3 factorial design. An inverse relationship between dietary calcium and systolic blood pressure as determined by the photoelectric tail cuff method became significant (p<0.05) after 12 weeks. Repeated measures analysis of variance indicated that dietary magnesium had no effect on systolic blood pressure; no calcium x magnesium interaction was observed. Total and ultrafiltrable serum calcium had a significant inverse correlation with blood pressure (-0.4642, p = .001 and -0.5568, p = .001 respectively). Total and ultrafiltrable serum magnesium reflected dietary magnesium concentration. Magnesium deficiency signs, deposition of calcium in kidneys, and histological lesions were observed in high calcium fed groups receiving normal and low levels of magnesium. Thus, a lowering of blood pressure by calcium supplementation without concomitant magnesium supplementation was accompanied by biochemical and histologic abnormalities in this animal model.
- Research Organization:
- Purdue Univ., West Lafayette, IN
- OSTI ID:
- 5414819
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CALCIUM
BIOLOGICAL EFFECTS
HYPERTENSION
PATHOGENESIS
MAGNESIUM
BIOLOGICAL MODELS
BLOOD PRESSURE
DIET
KIDNEYS
NUTRITIONAL DEFICIENCY
RATS
ALKALINE EARTH METALS
ANIMALS
BODY
CARDIOVASCULAR DISEASES
DISEASES
ELEMENTS
MAMMALS
METALS
ORGANS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology