Up- and down-regulation of beta-adrenoreceptors in rat cerebral cortex following exposure to isomers of hexachlorocyclohexane
The authors have shown that the gamma (lindane) and beta isomers of hexachlorocyclohexane (HCH) have opposite effects on the kindling model of epilepsy (gamma facilitates, beta retards kindling acquisition). In the present study the authors determined the effects of these two isomers on ..beta..-adrenoreceptors in rat brain using /sup 3/H-dihydroalprenolol as the ligand following 10 days treatment with 10 mg/kg p.o. of isomers or corn oil. Results showed a statistically significant decrease in the number of ..beta..-adrenoreceptors in cortical tissue taken from lindane treated rats. In contrast, there was a significant increase in the number of ..beta..-adreno receptors in cortical tissue taken from beta-HCH treated rats. Neither treatment caused a significant change in Kd. It is concluded that the ..beta..-adrenoreceptor system in rat brain is differentially affected by the isomers of HCH. Since the kindling model of epilepsy is sensitive to modulation in adrenergic function, this system may be involved in the pro- and anticonvulsant effects of these HCH isomers on kindling acquisition.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 5384805
- Report Number(s):
- CONF-8604222-; TRN: 86-030567
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
EPILEPSY
BIOLOGICAL MODELS
HEXANE
BIOLOGICAL EFFECTS
SYMPATHOMIMETICS
RECEPTORS
CEREBRAL CORTEX
LIGANDS
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALKANES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISEASES
DRUGS
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550901 - Pathology- Tracer Techniques