Effects of lindane on the glucose metabolism in rat brain cortex cells

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90168-Q· OSTI ID:6291133

Pulido, J A; del Hoyo, N; Perez-Albarsanz, M A ^[1]

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1. Univ. of Alcala, Madrid (Spain)

The influence of 0.5 mM {gamma}-hexachlorocyclohexane ({gamma}-HCH, lindane) on glucose transport has been investigated using the analog 3-O-methyl-D(U-{sup 14}C) glucose. The glucose uptake was lineal for at least 10 sec. Preincubation of dissociated brain cortex cells with lindane decreased the transport of glucose with respect to the controls. The treatment of brain cortex cells with other organochlorine compounds indicated that the {alpha}-, {delta}-HCH isomers and dieldrin reproduced the same inhibitory pattern, while {beta}-HCH and endrin were inactive. The total radioactivity incorporated into CO{sub 2} from (U-{sup 14}C) glucose in the cerebral cortex is also inhibited by lindane in a time dependent manner.

• OSTI ID: 6291133
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 47:13; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHLORINATED ALICYCLIC HYDROCARBONS
GLUCOSE
HALOGENATED ALICYCLIC HYDROCARBONS
HEXOSES
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LINDANE
MEMBRANE TRANSPORT
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
SACCHARIDES
TIME DEPENDENCE
TRACER TECHNIQUES