Endocrine responses in the rhesus monkey during acute cold exposure
- Naval Aerospace Medical Research Lab., Pensacola, FL (United States)
The authors studied five young male rhesus monkeys (Macaca mulatta), 3.4 to 6.7 kg, to determine the relationship between fluid balance hormones and urine production during acute, dry cold exposure. Each monkey served as its own control in duplicate experimental sessions at 6C or 26C. A 6-h experimental session consisted of 120 min equilibration at 26C, 120 min experimental exposure, and 120 min recovery at 26C. Urinary and venous catheters were inserted on the morning of a session. Rectal (Tre) and skin temperatures were monitored continuously. Blood samples were taken at 0, 30, 60 and 120 min of exposure, and at 60 min postexposure. Plasma was analyzed for arginine vasopressin (AVP), atrial natriuretic factor (ANF), plasma renin activity (PRA), plasma aldosterone (PA), and osmolality. Urine samples were analyzed for osmolality, electrolytes, and creatinine. Mean Tre was 1.6C lower after 120 min at 6C than at 26C. Urine volume and osmolality were not altered by cold exposure, as they are in humans and rats. Vasopressin and PA increased sharply, with mean plasma levels in monkeys exposed to cold more than threefold and tenfold, respectively, the levels in monkeys exposed at 26C. In contrast, ANF, PRA, and plasma osmolality were not significantly changed by cold exposure. The absence of a cold-induced diuresis in the monkey may be related to the marked increase in plasma AVP level.
- OSTI ID:
- 5374638
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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HYPOTHERMIA
BIOLOGICAL EFFECTS
URINE
CHEMICAL ANALYSIS
ACUTE EXPOSURE
ALDOSTERONE
BODY TEMPERATURE
ENDOCRINE GLANDS
METABOLISM
MONKEYS
PEPTIDES
TEMPERATURE EFFECTS
VASOPRESSIN
ADRENAL HORMONES
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CORTICOSTEROIDS
GLANDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
MATERIALS
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PRIMATES
PROTEINS
STEROID HORMONES
STEROIDS
VERTEBRATES
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560200* - Thermal Effects