High resolution proton magnetic resonance spectroscopy of human brain and liver

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Magn. Reson. Imag.; (United States)

DOI:https://doi.org/10.1016/0730-725X(87)90128-7· OSTI ID:5362693

Barany, M; Spigos, D G; Mok, E; Venkatasubramanian, P N; Wilbur, A C; Langer, B G

Water-suppressed and slice-selective proton spectra of live human brain exhibited several resonances that were tentatively assigned to metabolites such as N-acetylaspartate, glutamate, phosphocreatine and creatine, choline derivatives, and taurine. In the liver spectrum of a healthy volunteer, the major resonance was tentatively assigned to a fatty acyl methylene and the minor resonances to protons in carnitine, taurine, glutamate, and glutamine. In the spectrum of a cancerous liver, resonances in addition to those present in the normal liver were seen. Protein degradation in the liver with cancer was indicated by resonances from urea and from the ring protons in tryptophan, tyrosine, and phenylalanine. Furthermore, increased nucleic acid synthesis was indicated by resonances from nucleotide protons.

• Research Organization: Univ. of Illinois, Chicago
• OSTI ID: 5362693
• Journal Information: Magn. Reson. Imag.; (United States), Vol. 5:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NMR SPECTRA
LIVER
NEOPLASMS
DIAGNOSIS
MAN
METABOLITES
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEIC ACIDS
PROTONS
ANIMALS
BARYONS
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELEMENTARY PARTICLES
FERMIONS
GLANDS
HADRONS
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEONS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RESONANCE
SPECTRA
VERTEBRATES
550600* - Medicine