Effect of topical silver sulfadiazine on plasma copper, zinc and silver concentrations in a burn rat model
- Army Inst. of Surgery Research, Ft. Sam Houston, TX (United States)
One percent silver sulfadiazine cream (AgSD) is routinely used as a topical agent to prevent wound infection in burned patients. This report describes the effect of such topical therapy on plasma copper, silver and zinc concentrations in burned rats. Twelve male Sprague-Dawley rats received full thickness burns of 30% of the total body surface and were maintained for seven days on Purina Rat Chow and deionized water ad libitum. Twelve sham burned animals were similarly maintained. The wounds in six burned and a similar area in six sham burned animals were treated daily with 3 gms of AgSD, beginning on the day of injury. Blood was drawn on the seventh postburn day and analyzed for plasma copper, silver and zinc, using graphite furnace atomic absorption spectrophotometry. Silver absorption was associated with decreased plasma copper concentration in both burned and sham burned animals. Zinc concentrations did not differ significantly.
- OSTI ID:
- 5237950
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
METABOLISM
SILVER
SULFADIAZINE
BIOLOGICAL EFFECTS
ZINC
ABSORPTION SPECTRA
BURNS
RATS
SPECTROPHOTOMETRY
WOUNDS
AMIDES
AMINES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
AZINES
DRUGS
ELEMENTS
HETEROCYCLIC COMPOUNDS
INJURIES
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRIMIDINES
RODENTS
SPECTRA
SULFONAMIDES
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology