Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90588-7· OSTI ID:6676631

Sonntag, W E; Boyd, R L

The purpose of this study was to determine whether the generalized catabolic effects of chronic ethanol may be associated with a decline in plasma of insulin-like growth factor-1 (IGF-1). Male Sprague-Dawley rats were fed a liquid diet containing 5% ethanol or pair-fed a diet made isocaloric with maltose-dextrin. Animals were maintained on this diet for either 12 days or 4.5 months. Another groups of animals were fed control diet ad libitum for 2 weeks. After 12 days of feeding, plasma concentrations of IGF-1 in ad libitum fed rats were 771 +/- 41 ng/ml which was greater than concentrations in either pair-fed or ethanol-fed rats. After 4.5 months of feeding, plasma levels of IGF-1 in ad libitum and pair-fed rats were similar to the 12 day study. However, a significant decrease in plasma levels of IGF-1 was observed in ethanol-fed animals over the 4.5 month period. Results of a similar study in rats fed a high-fat diet for 4.5 months were similar to those found with the low-fat diet.

• Research Organization: Wake Forest Univ., Winston-Salem, NC (USA)
• OSTI ID: 6676631
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 43:16; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CHRONIC EXPOSURE
ETHANOL
GROWTH FACTORS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
INSULIN
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RATS
RODENTS
SYNTHESIS
VERTEBRATES