Exchange of potassium and strontium in adult bone. [Dogs]
The kinetics of exchange of strontium (/sup 85/Sr) and potassium (/sup 42/K) were studied in the midtibial cortical bone of 37 adult dogs. After injection of these two tracer cations and tracer-labeled albumin into the tibial nutrient artery, two types of observations were made: 1) collection of sequential venous samples to provide the outflow indicator-dilution curves and to calculate the extraction and retention at early times; and 2) detection of energy-selected gamma emissions via a detector over the tibia to give the time course of content of /sup 42/K and /sup 85/Sr in the tibia. Extractions of K/sup +/ and Sr/sup 2 +/ were 50 and 60% during a single transcapillary passage. More Sr/sup 2 +/ than K/sup +/ was retained in the first minutes. Their rates of washout over a 3-h period were similar. The interpretation is that the rate of uptake at extravascular sites is faster for Sr/sup 2 +/ than for K/sup +/, as is the rate of release, and that the extravascular volume of distribution for Sr/sup 2 +/ (adsorption sites in the interstitium or on bone) is much larger than that for K/sup +/ (intracellular).
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 5172863
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 242:4
- Country of Publication:
- United States
- Language:
- English
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Myocardial kinetics of thallium and potassium in man. [/sup 201/Tl, /sup 42/K, /sup 15/I, Tritium Oxides]
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Related Subjects
POTASSIUM 42
METABOLISM
SKELETON
RADIONUCLIDE KINETICS
RETENTION FUNCTIONS
STRONTIUM 85
ALBUMINS
BONE SEEKERS
DOGS
GAMMA DETECTION
ION EXCHANGE
RADIOCHEMICAL ANALYSIS
TRACER TECHNIQUES
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMICAL ANALYSIS
DAYS LIVING RADIOISOTOPES
DETECTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POTASSIUM ISOTOPES
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION DETECTION
RADIOISOTOPES
STRONTIUM ISOTOPES
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)