Outcome of asbestos exposure (lung fibrosis and antinuclear antibodies) with respect to skin reactivity: an 8-year longitudinal study

Journal Article · Wed Oct 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80162-1· OSTI ID:5088437

Lange, A; Garncarek, D; Tomeczko, J; Ciechanowski, G; Bisikiewicz, R

Two hundred seventy asbestos workers were examined during an 8-year period. During this time five consecutive surveys were completed. Skin tests with streptokinase-streptodornase (SK-SD), tuberculin (PPD), and phytohemagglutinin (PHA) were performed in the middle of this period. The results of these tests were related to X-ray chest film results and the appearance of antinuclear antibodies (ANA). In all surveys, except the first, X-ray films with small irregular opacities with a profusion greater than or equal to1/1 belonged more frequently to asbestos workers who did not respond to SK-SD or PHA. Thirty-one cases of asbestosis were diagnosed at that time, 23 of them became asbestotic after the skin tests were performed. Asbestotic cases contributed more frequently to the group with energy as compared to asbestos workers lacking asbestosis. Furthermore, asbestosis was correlated with lack of response to second strength of SK-SD in males and PHA in both sexes. Lack of response to these activators was predictive of asbestosis. Asbestos workers with ANA frequently displayed a lack of response to the first strength of SK-SD, PPD, and PHA. This was partly due to the presence of asbestotic cases in the group. However, low responders to all these activators were found frequently in the group with ANA independent of the presence of asbestosis.

• Research Organization: Institute of Immunology and Experimental Therapy, Wroclaw, Poland
• OSTI ID: 5088437
• Journal Information: Environ. Res.; (United States), Vol. 41:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ASBESTOS
HEALTH HAZARDS
LUNGS
BIOMEDICAL RADIOGRAPHY
FIBROSIS
OCCUPATIONAL DISEASES
DIAGNOSIS
RESPIRATORY SYSTEM DISEASES
EPIDEMIOLOGY
EXPERIMENTAL DATA
IMMUNE REACTIONS
MEDICAL SURVEILLANCE
OCCUPATIONAL EXPOSURE
SKIN
BODY
DATA
DIAGNOSTIC TECHNIQUES
DISEASES
HAZARDS
INFORMATION
MEDICINE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
RADIOLOGY
RESPIRATORY SYSTEM
SURVEILLANCE
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
550602 - Medicine- External Radiation in Diagnostics- (1980-)