Alteration of T cell function in healthy persons with a history of thymic x irradiation
Journal Article
·
· J. Allergy Clin. Immunol.; (United States)
The possible late effects of x irradiation to the infantile thymus were investigated by studying immune functions in 12 healthy persons with a history of thymic x irradiation and healthy control subjects. No differences were found in serum immunoglobulin values, humoral antibody levels, lymphocyte counts, and lymphocyte reactivity to phytohemagglutinin, vaccinia virus, purified protein derivative (PPD), and allogeneic cells. The irradiation group exhibited cellular hyperresponsiveness to streptokinase-streptodornase (SK-SD). In contrast, mean skin and in vitro lymphocyte responses to Candida albicans were depressed in the patients with thymic irradiation. A dissociation of these two Candida responses was found in only 1 of 14 healthy control subjects but in 7 of 12 irradiated individuals. While thymic irradiation did not result in impaired immunologic defenses leading to clinical disease, it caused alterations in T cell responses similar to those reported in patients with chronic mucocutaneous candidiasis.
- Research Organization:
- Univ. of Chicago
- OSTI ID:
- 7275990
- Journal Information:
- J. Allergy Clin. Immunol.; (United States), Journal Name: J. Allergy Clin. Immunol.; (United States) Vol. 56:4; ISSN JACIB
- Country of Publication:
- United States
- Language:
- English
Similar Records
B and T lymphocytes in man. I. Effect of infant thymic irradiation on the circulating B and T lymphocytes
Immunologic competence in adults following thymic irradiation in infancy
Receptor activity of sorted lymphoid cells with a thymic regulatory factor
Conference
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:4053576
Immunologic competence in adults following thymic irradiation in infancy
Conference
·
Fri Jul 01 00:00:00 EDT 1977
· Radiology; (United States)
·
OSTI ID:7221734
Receptor activity of sorted lymphoid cells with a thymic regulatory factor
Journal Article
·
Thu Jan 12 23:00:00 EST 1978
· Biochem. Biophys. Res. Commun.; (United States)
·
OSTI ID:7026535
Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHILDREN
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GLOBULINS
IMMUNE REACTIONS
IMMUNOGLOBULINS
INFANTS
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MAN
NEONATES
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
THYMUS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHILDREN
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GLOBULINS
IMMUNE REACTIONS
IMMUNOGLOBULINS
INFANTS
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MAN
NEONATES
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
THYMUS
VERTEBRATES
X RADIATION