Receptor activity of sorted lymphoid cells with a thymic regulatory factor

Journal Article · Fri Jan 13 04:00:00 EST 1978 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(78)91132-4· OSTI ID:7026535

Mednieks, M I; Cram, S L; Juras, D S

A small molecular-weight regulatory factor from the thymus has been shown to enhance both cell-mediated and humoral immune responses. In this study, the relative binding capacity of the factor to thymus-dependent and bone marrow-dependent lymphocytes was measured directly. Spleen cells were separated using an automated, multiparameter, cell sorting instrument. Receptor activity for the iodinated thymic protein of each population was determined. Based on a number of criteria, thymus-dependent cells exhibited a greater affinity for the regulatory protein than did the bone marrow-dependent cells. These results indicate that the mechanism of action of regulatory control is via receptor-ligand interactions of specific subpopulations of lymphoid cells with a humoral factor.

• Research Organization: Northwestern Univ., Chicago
• OSTI ID: 7026535
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 80:1; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IMMUNOLOGY
LEUKOCYTES
LIGANDS
LYMPHATIC SYSTEM
LYMPHOCYTES
MOLECULAR WEIGHT
ORGANIC COMPOUNDS
ORGANS
PROTEINS
SOMATIC CELLS
SPLEEN
THYMUS
TISSUES