Radioimmunodetection of cutaneous T-cell lymphoma with 111In-labeled T101 monoclonal antibody

Journal Article · Thu Sep 11 00:00:00 EDT 1986 · N.Engl. J. Med.; (United States)

DOI:https://doi.org/10.1056/NEJM198609113151104· OSTI ID:5073070

Carrasquillo, J A; Bunn, Jr, P A; Keenan, A M; Reynolds, J C; Schroff, R W; Foon, K A; Su, M H; Gazdar, A F; Mulshine, J L; Oldham, R K

T101 monoclonal antibody recognizes a pan-T-cell antigen present on normal T cells and also found in high concentrations in cutaneous T-cell lymphoma. We used this antibody, radiolabeled with 111In, in gamma-camera imaging to detect sites of metastatic cutaneous T-cell lymphoma in 11 patients with advanced disease. In all patients, (/sup 111/In)T101 concentrated in pathologically or clinically detected nodes, including those in several previously unsuspected nodal regions. Concentrations (per gram of tissue) ranged from 0.01 to 0.03 percent of the injected dose and were consistently 10 to 100 times higher than previously reported on radioimmunodetection. Focal uptake was seen in skin tumors and heavily infiltrated erythroderma but not in skin plaques. The specificity of tumor targeting was documented by control studies with (/sup 111/In)chloride or (/sup 111/In)9.2.27 (anti-melanoma) monoclonal antibody. Increasing the T101 dose (1 to 50 mg) altered distribution in nontumor tissues. These studies suggest that imaging with (/sup 111/In)T101 may be of value in identifying sites of cutaneous T-cell lymphoma. In contrast to the targeting of solid tumors, the mechanism of localization appears to be related to binding to T cells, which can then carry the radioactivity to involved sites.

• Research Organization: National Cancer Institute, Bethesda, MD
• OSTI ID: 5073070
• Journal Information: N.Engl. J. Med.; (United States), Vol. 11
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
LYMPHOMAS
DIAGNOSIS
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
IMAGES
INDIUM 111
LABELLED COMPOUNDS
LYMPH NODES
METASTASES
PATIENTS
SPECIFICITY
ANTIBODIES
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
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ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
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MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics