Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses
The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5071635
- Journal Information:
- J. Immunol.; (United States), Vol. 132:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIBODY FORMATION
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
BRUCELLA
IMMUNOLOGY
MICE
PARTIAL BODY IRRADIATION
THYMUS CELLS
WHOLE-BODY IRRADIATION
X RADIATION
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals