Process for the production of /sup 18/F-2-deoxy-2-fluoro-D-glucose

Patent · Tue Oct 14 00:00:00 EDT 1986

OSTI ID:5030827

Elmaleh, D R; Levy, S; Shiue, C Y; Wolf, A P

A process is described for the production of /sup 18/F-2-deoxy-2-fluoro-D-glucose which comprises the steps of: (a) producing a compound; (b) reacting the resulting compound with a fluorinating agent in an inert organic solvent with heating at 100/sup 0/C. to 150/sup 0/C; and (c) hydrolyzing the resulting compounds to remove alkyl groups with BBr/sub 3/, BC1/sub 3/ or concentrated hydrochloric acid.

• Assignee: Dept. of Energy, Washington, DC
• Patent Number(s): US 4617386
• Application Number: TRN: 86-036536
• OSTI ID: 5030827
• Resource Relation: Patent File Date: Filed date 25 Apr 1983
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
FLUORINE 18
CHEMICAL PREPARATION
FLUORINE COMPOUNDS
GLUCOSE
ANHYDRIDES
BORON BROMIDES
BORON CHLORIDES
FLUORINATION
HIGH TEMPERATURE
HYDROCHLORIC ACID
HYDROLYSIS
MEDIUM TEMPERATURE
METHANE
ORGANIC SOLVENTS
ALDEHYDES
ALKANES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON COMPOUNDS
BROMIDES
BROMINE COMPOUNDS
CARBOHYDRATES
CHEMICAL REACTIONS
CHLORIDES
CHLORINE COMPOUNDS
DECOMPOSITION
FLUORINE ISOTOPES
HALIDES
HALOGEN COMPOUNDS
HALOGENATION
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROCARBONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
ISOTOPES
LIGHT NUCLEI
LYSIS
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SOLVENTS
SOLVOLYSIS
SYNTHESIS
400301* - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)