Effect of dietary cellulose on site of lipid absorption
The effect of dietary cellulose on the localization within the small intestine of isotopically labeled triglyceride (TG) and cholesterol (CH) from a test meal was investigated. Feeding a 20% cellulose meal resulted in greater quantities of /sup 14/C-TG present in both the contents and mucosa of the distal intestine compared with a fiber-free control meal. In contrast, cellulose had no effect on the localization of CH within either the intestinal contents or the mucosa. Accumulation of TG within the intestine was not due to differences in stomach emptying, as the emptying rate was similar for both TG and CH. Within the bulk phase TG must be hydrolyzed by pancreatic lipase before it is available for cellular uptake at the microvillus membrane, whereas CH requires no hydrolysis. The greater amount of TG, but not of CH, within the intestine suggests that cellulose can interfere with lipase activity in vivo. Consequently, cellulose can delay TG hydrolysis and increase the amount of lipid absorbed in the ileum.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 5022780
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States)
- Country of Publication:
- United States
- Language:
- English
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CELLULOSE
BIOLOGICAL EFFECTS
CHOLESTEROL
BIOLOGICAL LOCALIZATION
INTESTINAL ABSORPTION
LIPASE
ENZYME ACTIVITY
TRIGLYCERIDES
BILE
DIET
DIGESTION
HYDROLYSIS
LIVER
RATS
SMALL INTESTINE
TISSUE DISTRIBUTION
TRITIUM
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
CARBOXYLESTERASES
CHEMICAL REACTIONS
DECOMPOSITION
DIGESTIVE SYSTEM
DISTRIBUTION
ENZYMES
ESTERASES
ESTERS
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN ISOTOPES
HYDROLASES
HYDROXY COMPOUNDS
INTESTINES
ISOTOPES
LIGHT NUCLEI
LIPIDS
LYSIS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RODENTS
SACCHARIDES
SOLVOLYSIS
STEROIDS
STEROLS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550501* - Metabolism- Tracer Techniques