Intestinal permeability to (/sup 51/Cr)EDTA in children with cystic fibrosis

Journal Article · Thu May 01 00:00:00 EDT 1986 · J. Pediatr. Gastroenterol. Nutr.; (United States)

DOI:https://doi.org/10.1097/00005176-198605000-00008· OSTI ID:5019752

Leclercq-Foucart, J; Forget, P; Sodoyez-Goffaux, F; Zappitelli, A

Intestinal permeability was investigated in 14 children with cystic fibrosis making use of (/sup 51/Cr)EDTA as probe molecule. Ten normal young adults and 11 children served as controls. After oral administration of (/sup 51/Cr)EDTA, 24 h urine was collected. Urinary radioactivity was calculated and results expressed as percentage of oral dose excreted in 24 h urine. Mean and SEM were as follows: 2.51 +/- 0.21, 2.35 +/- 0.24, and 13.19 +/- 1.72 for control children, normal adults, and cystic fibrosis patients, respectively. The permeability differences between cystic fibrosis patients and either control children or control adults are significant (p less than 0.001).

• OSTI ID: 5019752
• Journal Information: J. Pediatr. Gastroenterol. Nutr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHROMIUM 51
INTESTINAL ABSORPTION
EDTA
CHILDREN
METABOLIC DISEASES
PATHOGENESIS
PERMEABILITY
ABSORPTION
AGE GROUPS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
UPTAKE
550601* - Medicine- Unsealed Radionuclides in Diagnostics