Relationship between intestinal permeability to ( sup 51 Cr)EDTA and inflammatory activity in asymptomatic patients with Crohn's disease

Journal Article · Tue May 01 00:00:00 EDT 1990 · Digestive Diseases and Sciences; (USA)

DOI:https://doi.org/10.1007/BF01540405· OSTI ID:6870263

Pironi, L; Miglioli, M; Ruggeri, E; Levorato, M; Dallasta, M A; Corbelli, C; Nibali, M G; Barbara, L ^[1]

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1. Univ. of Bologna (Italy)

The relationship between intestinal permeability to an oral dose (100 mu Ci) of (51CR)EDTA and the inflammatory activity of Crohn's disease was studied in 63 adult patients (32 unresected and 31 resected) who underwent 162 evaluations. The results of the (51CR)EDTA test were compared with the serum levels of the acute-phase reactant proteins (APRP) and with the result of the (111In)leukocyte scanning, respectively, as an indirect and direct method to assess intestinal inflammation. In a group of healthy adult controls, the upper normal value for the 24-hr urinary (51CR)EDTA excretion was 3.61 (97.5% percentile) and the mean coefficient of variation was 21%. Sensitivity and specificity of the (51CR)EDTA test in identifying active inflammation expressed by increased serum levels of APRP were, respectively, 97% and 54% in the unresected group and 68% and 52% in the resected group of patients. The low specificity of the test was due to the presence of increased (51CR)EDTA urinary excretion in about half the cases with normal serum levels of APRP. The (111In)leukocyte scanning was performed in a subgroup of 11 patients (three unresected and eight resected) with normal serum levels of APRP, six with increased and five with normal (51CR)EDTA urinary excretion. All six patients with increased intestinal permeability had a positive 111In image of mild to moderate degree of activity. A positive 111In scan was present in two of the five patients with normal permeability; these were two resected patients.

• OSTI ID: 6870263
• Journal Information: Digestive Diseases and Sciences; (USA), Vol. 35:5; ISSN 0163-2116
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
INTESTINES
RADIOISOTOPE SCANNING
MUCOUS MEMBRANES
PERMEABILITY
CHROMIUM 51
EDTA
INDIUM 111
INTESTINAL ABSORPTION
LEUKOCYTES
MAN
PATIENTS
PROTEINS
SENSITIVITY ANALYSIS
ABSORPTION
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
UPTAKE
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics