Dioxinlike properties of a trichloroethylene combustion-generated aerosol

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Environmental Health Perspectives

DOI:https://doi.org/10.1289/ehp.96104734· OSTI ID:471879

Villalobos, S A; Anderson, M J; Hinton, D E ^[1]

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1. Univ. of California, Davis, CA (United States); and others

Conventional chemical analyses of incineration by-products identify compounds of known toxicity but often fail to indicate the presence of other chemicals that may pose health risks. In a previous report, extracts from soot aerosols formed during incomplete combustion of trichloroethylene (TCE) and pyrolysis of plastics exhibited a dioxinlike response when subjected to a keratinocyte assay. To verify this dioxinlike effect, the complete extract, its polar and nonpolar fractions, some containing primarily halogenated aromatic hydrocarbons, were evaluated for toxicity using an embryo assay, for antiestrogenicity using primary liver cell cultures, and for the ability to transform the aryl hydrocarbon receptor into its DNA binding form using liver cytosol in a gel retardation assay. Each of these assays detect dioxinlike effects. Medaka (Oryzias latipes) embryos and primary liver cell cultures of rainbow trout (Oncorhynchus mykiss) were exposed to concentrations of extract ranging from 0.05 to 45 {mu}g/l. 67 refs., 7 figs., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 471879
• Journal Information: Environmental Health Perspectives, Vol. 104, Issue 7; Other Information: PBD: Jul 1996
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
09 BIOMASS FUELS
DIOXIN
BIOLOGICAL EFFECTS
INDUSTRIAL WASTES
COMBUSTION
AEROSOLS
CELL CULTURES
DNA
EMBRYOS
HALOGENATED AROMATIC HYDROCARBONS
LACTATE DEHYDROGENASE
LIVER CELLS
SOOT
TOXICITY
HAZARDOUS MATERIALS
CHLORINATED ALIPHATIC HYDROCARBONS
TROUT
PLASTICS
AIR POLLUTION