The use of SCID mice in biotechnology and as a model for human disease
- Univ. of Toronto, Ontario (Canada). Dept. of Surgery
- Mount Sinai Hospital, Toronto, Ontario (Canada). Samuel Lunenfeld Research Inst.
The use of SCID (severe combined immunodeficient) mice in medical research and biotechnology has increased tremendously in recent years. This review outlines the major characteristics of these animals and the impediments that they poise to the engraftment of human cells and tissues. The development of the SCID mice pretreatment protocol (anti-asialo GM 1 antisera and radiation) is described, and the results of xenotransplantation studies of human cells and tissues in these pretreated animals are outlined. Wherever possible, data from transplantation studies (of human tissues and cells) in pretreated and nonpretreated animals are compared. The potential of the pretreated SCID mice for medical research and biotechnology is discussed.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 227861
- Journal Information:
- CRC Critical Reviews in Biotechnology, Vol. 16, Issue 1; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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