First results on cell irradiation with laser-driven protons on the TARANIS system

Journal Article · Fri Jul 26 00:00:00 EDT 2013 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4816612· OSTI ID:22218283

Kar, S.; Doria, D.; Kakolee, K. F.; Prasad, R.; Litt, S.; Ahmed, H.; Nersisyan, G.; Lewis, C.; Zepf, M. ^[1]; Borghesi, M. ^[2]; Schettino, G.; Prise, K. M. ^[3]; Fiorini, F.; Kirby, D.; Green, S. ^[4]; Jeynes, J. C. G.; Merchant, M. J.; Kirkby, K. J. ^[5]

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1. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
2. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN, UK and Institute of Physics of the ASCR, ELI-Beamlines Project, Prague (Czech Republic)
3. CCRCB, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
4. Dept. of Medical Physics, University Hospital, Birmingham, B15 2TH (United Kingdom)
5. Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom)

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen’s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9} Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

• OSTI ID: 22218283
• Journal Information: AIP Conference Proceedings, Vol. 1546, Issue 1; Conference: 2. ELIMED workshop and panel, Catania (Italy), 18-19 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL RADIATION EFFECTS
COMPARATIVE EVALUATIONS
DOSE RATES
EQUIVALENT RADIATION DOSES
IRRADIATION
MEV RANGE
PROTON BEAMS
PROTONS
RADIOTHERAPY
RBE
X-RAY SOURCES