Evaluation of Degradation Properties of Polyglycolide and Its Potential as Delivery Vehicle for Anticancer Agents
- Advanced Materials Research Centre (AMREC), SIRIM Berhad, Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim Kedah (Malaysia)
Biodegradable polymers offer a unique combination of properties that can be tailored to suit nearly any controlled drug delivery application. The most common biodegradable polymers used for biomedical applications are semicrystalline polyesters and polyethers which possess good mechanical properties and have been used in many controlled release applications. Drug release from these polymers may be controlled by several mechanisms and these include diffusion of drug through a matrix, dissolution of polymer matrix and degradation of the polymer. This study aims to investigate the degradation and drug release properties of polyglycolide (1.03 dL/g), in which, cis platin, an anticancer agent was used as the model drug. The degradation behaviour of the chosen polymer is thought to largely govern the release of the anticancer agent in vitro.
- OSTI ID:
- 21371676
- Journal Information:
- AIP Conference Proceedings, Vol. 1217, Issue 1; Conference: ICAMN-2007: International conference on advancement of materials and nanotechnology, Langkawi, Kedah (Malaysia), 29 May - 1 Jun 2007; Other Information: DOI: 10.1063/1.3377819; (c) 2010 American Institute of Physics; ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
BIOLOGICAL MATERIALS
DELIVERY
DIFFUSION
DISSOLUTION
DNA
DRUGS
IN VITRO
MATRIX MATERIALS
MECHANICAL PROPERTIES
POLYESTERS
POLYETHYLENE GLYCOLS
X-RAY DIFFRACTION
ALCOHOLS
COHERENT SCATTERING
DIFFRACTION
ESTERS
GLYCOLS
HYDROXY COMPOUNDS
MATERIALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
POLYMERS
SCATTERING