Investigation of Degradation Properties of Poly(lactide-co-glycolide) Matrix for Anticancer Agent Delivery

Journal Article · Thu Mar 11 00:00:00 EST 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3377816· OSTI ID:21371675

Ghani, S M; Mohamed, M S. W.; Yahya, A F; Noorsal, K ^[1]

---

1. Advanced Materials Research Centre (AMREC), SIRIM Berhad, Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim Kedah (Malaysia)

Poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) is a biodegradable and biocompatible polymer. It offers tremendous potential as a basis for drug delivery, either as drug delivery system alone or in conjugate with a medical device. The PLA{sub 50}GA{sub 50} is the material of choice for relatively shorter-duration applications, while the homopolymer PLA (poly-L-lactide) and PGA (polyglycolide) are preferred for longer term delivery of drugs. This paper discusses the degradation properties of poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) at inherent viscosity of 0.89 dL/g as preliminary studies for anticancer agent delivery.

• OSTI ID: 21371675
• Journal Information: AIP Conference Proceedings, Vol. 1217, Issue 1; Conference: ICAMN-2007: International conference on advancement of materials and nanotechnology, Langkawi, Kedah (Malaysia), 29 May - 1 Jun 2007; Other Information: DOI: 10.1063/1.3377816; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
BIOLOGICAL MATERIALS
CRYSTALLIZATION
DECOMPOSITION
DELIVERY
DRUGS
MATRIX MATERIALS
ORGANIC POLYMERS
VISCOSITY
X-RAY DIFFRACTION
CHEMICAL REACTIONS
COHERENT SCATTERING
DIFFRACTION
MATERIALS
ORGANIC COMPOUNDS
PHASE TRANSFORMATIONS
POLYMERS
SCATTERING