Signal transduction images in human brain by positron emission tomography
- Kyoto Prefectural Univ. of Medicine (Japan); and others
Analysis of changes in intracellular signal transduction will provide clear images of the projected target neurons. We have recently developed a technique which allows second-messenger imaging of changes in intracellular signal transduction which is activated in parallel with phosphoinositide (PI) turnover. Using carbon-11-labeled 1,2-diacylglycerol (DAG), we have recently succeeded in making an image of intracellular signal transduction during the course of synaptic transmission in human brains. When five healthy volunteers were examined by this technique, they had high activity in the associate field, in particular the prefrontal area. In the absence of paradigm loading, the associate field was unilaterally active, and human subjects showed predominant activity in the right prefrontal area. Activation of the ipsilateral supraorbital region and the superior temporal area was also seen at the same time. In conclusion, no previous study has directly demonstrated the unilateral predominance of the activity in the associate fields (projected target area) and the accompanying areas. Unlike the conventional positron-labeled compounds which did not permit visualization of activation of the associate fields, our technique can measure the PI turnover, as a postsynaptic response, and thus provide clear images of the projected target nerve cells in relation to higher cortical function in human brain.
- OSTI ID:
- 197986
- Report Number(s):
- CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0126
- Journal Information:
- Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
- Country of Publication:
- United States
- Language:
- English
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