Preparation of astatine-labeled monoclonal antibodies
Journal Article
·
· Radiochemistry
OSTI ID:171785
- Joint Inst. for Nuclear Research, Dubna (Russian Federation)
In the cationic state astatine forms a stable complex with diethylenetriaminepentaacetic acid. Thanks to this complex, astatine can be bound to monoclonal antibodies of the RYa{sub 1} type. The most favorable conditions for preparing astatine-labeled antibodies are established. The chromatographic analysis and electromigration experiments showed that astatine is firmly linked to a biomolecule in vitro and it did not escape from labeled monoclonal antibodies even under treatment with such highly effective astatine-complexing agent as thiourea. The immune activity of astatine-labeled antibodies did not change even after 20 h.
- OSTI ID:
- 171785
- Journal Information:
- Radiochemistry, Vol. 37, Issue 3; Other Information: PBD: Jul-Aug 1995; TN: Translated from Radiokhimiya; 37: No. 3, 253-257(1995)
- Country of Publication:
- United States
- Language:
- English
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