Structural Basis of Arc Binding to Synaptic Proteins: Implications for Cognitive Disease

Zhang, Wenchi; Wu, Jing; Ward, Matthew D.; Yang, Sunggu; Chuang, Yang-An; Xiao, Meifang; Li, Ruojing; Leahy, Daniel J.; Worley, Paul F.

doi:10.1016/j.neuron.2015.03.030

Title: Structural Basis of Arc Binding to Synaptic Proteins: Implications for Cognitive Disease

Journal Article · Thu Apr 09 00:00:00 EDT 2015 · Neuron

DOI:https://doi.org/10.1016/j.neuron.2015.03.030· OSTI ID:1213728

Zhang, Wenchi ^[1]; Wu, Jing ^[1]; Ward, Matthew D. ^[2]; Yang, Sunggu ^[3]; Chuang, Yang-An ^[1]; Xiao, Meifang ^[1]; Li, Ruojing ^[4]; Leahy, Daniel J. ^[2]; Worley, Paul F. ^[1]

Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine, Solomon H. Snyder Dept. of Neuroscience
Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine, Dept. of Biophysics and Biophysical Chemistry
Incheon National Univ. (Korea). Dept. of Nano-Bioengineering
Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine, Dept. of Pharmacology and Molecular Sciences

Arc is a cellular immediate-early gene (IEG) that functions at excitatory synapses and is required for learning and memory. Here we report crystal structures of Arc subdomains that form a bi-lobar architecture remarkably similar to the capsid domain of human immunodeficiency virus (HIV) gag protein. Analysis indicates Arc originated from the Ty3/Gypsy retrotransposon family and was “domesticated” in higher vertebrates for synaptic functions. The Arc N-terminal lobe evolved a unique hydrophobic pocket that mediates intermolecular binding with synaptic proteins as resolved in complexes with TARPγ2 (Stargazin) and CaMKII peptides and is essential for Arc’s synaptic function. A consensus sequence for Arc binding identifies several additional partners that include genes implicated in schizophrenia. Arc N-lobe binding is inhibited by small chemicals suggesting Arc’s synaptic action may be druggable. Finally, these studies reveal the remarkable evolutionary origin of Arc and provide a structural basis for understanding Arc’s contribution to neural plasticity and disease.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: RO1 MH053608

OSTI ID:: 1213728

Journal Information:: Neuron, Vol. 86, Issue 2; ISSN 0896-6273

Publisher:: Cell Press / ElsevierCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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