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Title: Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making

Patent ·
OSTI ID:1082680
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The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.

Research Organization:
US Department of Energy (USDOE), Washington, DC (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
3548
Assignee:
U.S. Department of Energy (Washington, DC)
Patent Number(s):
8,362,047
Application Number:
12/822,243
OSTI ID:
1082680
Resource Relation:
Patent File Date: 2010 Jun 24
Country of Publication:
United States
Language:
English

References (2)

Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology journal July 2007
High-Throughput Screening--Based Identification of Paramyxovirus Inhibitors journal July 2008

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