Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response
Abstract
Pollen grains are the male gametophytes that deliver sperm cells to female gametophytes during sexual reproduction of higher plants. Pollen is a major source of aeroallergens and environmental antigens. The pollen coat harbors a plethora of lipids that are required for pollen hydration, germination, and penetration of the stigma by pollen tubes. In addition to proteins, pollen displays a wide array of lipids that interact with the human immune system. Prior searches for pollen allergens have focused on the identification of intracellular allergenic proteins, but have largely overlooked much of the extracellular pollen matrix, a region where the majority of lipid molecules reside. Lipid antigens have attracted attention for their potent immunoregulatory effects. By being in close proximity to allergenic proteins on the pollen surface when they interact with host cells, lipids could modify the antigenic properties of proteins. We performed a comparative pollen lipid profiling of 22 commonly allergenic plant species by the use of gas chromatography-mass spectroscopy, followed by detailed data mining and statistical analysis. Three experiments compared pollen lipid profiles. We built a database library of the pollen lipids by matching acquired pollen-lipid mass spectra and retention times with the NIST/EPA/NIH mass-spectral library. We detected, identified, andmore »
- Authors:
-
- University of Chicago, IL (United States)
- University of Chicago, IL (United States); University of Arizona, Tucson, AZ (United States)
- University of Chicago, IL (United States); Chromatin, Inc., Chicago, IL (United States)
- Publication Date:
- Research Org.:
- University of Chicago, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); Strategic Program for Asthma Research; National Science Foundation (NSF); McHugh Otolaryngology Research Fund
- OSTI Identifier:
- 1904580
- Grant/Contract Number:
- FG02-96ER20240; MCB-0520283
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 2; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; pollen; lipids; allergies; immune response; cytokines; gas chromatography-mass spectrometry; lipid analysis; inflammation
Citation Formats
Bashir, Mohamed H., Lui, Jan Hsi, Palnivelu, Ravishankar, Naclerio, Robert M., and Preuss, Daphne. Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response. United States: N. p., 2013.
Web. doi:10.1371/journal.pone.0057566.
Bashir, Mohamed H., Lui, Jan Hsi, Palnivelu, Ravishankar, Naclerio, Robert M., & Preuss, Daphne. Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response. United States. https://doi.org/10.1371/journal.pone.0057566
Bashir, Mohamed H., Lui, Jan Hsi, Palnivelu, Ravishankar, Naclerio, Robert M., and Preuss, Daphne. Thu .
"Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response". United States. https://doi.org/10.1371/journal.pone.0057566. https://www.osti.gov/servlets/purl/1904580.
@article{osti_1904580,
title = {Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response},
author = {Bashir, Mohamed H. and Lui, Jan Hsi and Palnivelu, Ravishankar and Naclerio, Robert M. and Preuss, Daphne},
abstractNote = {Pollen grains are the male gametophytes that deliver sperm cells to female gametophytes during sexual reproduction of higher plants. Pollen is a major source of aeroallergens and environmental antigens. The pollen coat harbors a plethora of lipids that are required for pollen hydration, germination, and penetration of the stigma by pollen tubes. In addition to proteins, pollen displays a wide array of lipids that interact with the human immune system. Prior searches for pollen allergens have focused on the identification of intracellular allergenic proteins, but have largely overlooked much of the extracellular pollen matrix, a region where the majority of lipid molecules reside. Lipid antigens have attracted attention for their potent immunoregulatory effects. By being in close proximity to allergenic proteins on the pollen surface when they interact with host cells, lipids could modify the antigenic properties of proteins. We performed a comparative pollen lipid profiling of 22 commonly allergenic plant species by the use of gas chromatography-mass spectroscopy, followed by detailed data mining and statistical analysis. Three experiments compared pollen lipid profiles. We built a database library of the pollen lipids by matching acquired pollen-lipid mass spectra and retention times with the NIST/EPA/NIH mass-spectral library. We detected, identified, and relatively quantified more than 106 lipid molecular species including fatty acids, n-alkanes, fatty alcohols, and sterols. Pollen derived lipids stimulation up-regulate cytokines expression of dendritic and natural killer T cells co-culture. Here we report on a lipidomic analysis of pollen lipids that can serve as a database for identifying potential lipid antigens and/or novel candidate molecules involved in allergy. The database provides a resource that facilitates studies on the role of lipids in the immunopathogenesis of allergy. Pollen lipids vary greatly among allergenic species and contain many molecules that have stimulatory or regulatory effects on immune responses.},
doi = {10.1371/journal.pone.0057566},
journal = {PLoS ONE},
number = 2,
volume = 8,
place = {United States},
year = {Thu Feb 28 00:00:00 EST 2013},
month = {Thu Feb 28 00:00:00 EST 2013}
}
Works referenced in this record:
Gas-particle concentration and distribution of n-alkanes and polycyclic aromatic hydrocarbons in the atmosphere of Prato (Italy)
journal, June 2007
- Cincinelli, Alessandra; Bubba, Massimo Del; Martellini, Tania
- Chemosphere, Vol. 68, Issue 3
Induction of lupus autoantibodies by adjuvants
journal, August 2003
- Satoh, M.
- Journal of Autoimmunity, Vol. 21, Issue 1
Cytokine production and DNA synthesis by Human peripheral Lymphocytes in response to Palmitic, Stearic, Oleic, and Linoleic acid
journal, October 1994
- Karsten, S.; Schäfer, G.; Schauder, P.
- Journal of Cellular Physiology, Vol. 161, Issue 1
Regulation of immunity by self-reactive T cells
journal, June 2005
- Kronenberg, Mitchell; Rudensky, Alexander
- Nature, Vol. 435, Issue 7042
Rapid initiation of Arabidopsis pollination requires the oleosin-domain protein GRP17
journal, January 2000
- Mayfield, Jacob A.; Preuss, Daphne
- Nature Cell Biology, Vol. 2, Issue 2
Epidemia de asma por soja en L’Hospitalet de Llobregat (Barcelona)
journal, October 1997
- Pont, F.; Gispert, X.; Cañete, C.
- Archivos de Bronconeumología, Vol. 33, Issue 9
Identification of volatile organic compounds emitted in the field by oilseed rape (Brassica napusssp.oleifera) over the growing season
journal, March 1998
- Mcewan,
- Clinical & Experimental Allergy, Vol. 28, Issue 3
Palmitic acid induces IP-10 expression in human macrophages via NF-κB activation
journal, June 2007
- Laine, Phyllis S.; Schwartz, Eric A.; Wang, Yingjie
- Biochemical and Biophysical Research Communications, Vol. 358, Issue 1
The burden of allergic rhinitis
journal, January 2007
- Nathan, Robert A.
- Allergy and Asthma Proceedings, Vol. 28, Issue 1
Peroxisome Proliferator-Activated Receptor alpha, delta, gamma1 and gamma2 Expressions are Present in Human Monocyte-Derived Dendritic Cells and Modulate Dendritic Cell Maturation by Addition of Subtype-Specific Ligands
journal, May 2006
- Jakobsen, M. A.; Petersen, R. K.; Kristiansen, K.
- Scandinavian Journal of Immunology, Vol. 63, Issue 5
New Advances and Potential Therapies for the Treatment of Asthma
journal, January 2004
- Belvisi, Maria G.; Hele, David J.; Birrell, Mark A.
- BioDrugs, Vol. 18, Issue 4
Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab)
journal, January 2006
- D??Amato, Gennaro; Bucchioni, Enrica; Oldani, Virginio
- Treatments in Respiratory Medicine, Vol. 5, Issue 6
Nutrients, Nuclear Receptors, Inflammation, Immunity Lipids, PPAR, and Allergic Asthma
journal, March 2006
- August, Avery; Mueller, Cynthia; Weaver, Veronika
- The Journal of Nutrition, Vol. 136, Issue 3
The Effects of Temperature and Oleic Acid on Murine Memory and Virgin T Cell Activation: Interleukin-2 Secretion and Interleukin-2 Receptor Expression
journal, November 1993
- Wooten, R. Mark; Clem, L. William; Bly, Jan E.
- Cellular Immunology, Vol. 152, Issue 1
Constituents of the tapetosomes and elaioplasts inBrassica campestristapetum and their degradation and retention during microsporogenesis
journal, December 1998
- Ting, Julie T. L.; Wu, Sherry S. H.; Ratnayake, Chandra
- The Plant Journal, Vol. 16, Issue 5
Allergic respiratory diseases and environmental pollution: experience in the printing/paper-manufacturing industry
journal, November 1996
- Papa, G.; Quaratino, D.; Fonso, M. Di
- Allergy, Vol. 51, Issue 11
Identification of soybean dust as an epidemic asthma agent in urban areas by molecular marker and RAST analysis of aerosols
journal, July 1991
- Aceves, Merce; Grimalt, Joan O.; Sunyer, Jordi
- Journal of Allergy and Clinical Immunology, Vol. 88, Issue 1
Genetic Evidence for a Long-Range Activity That Directs Pollen Tube Guidance in Arabidopsis.
journal, January 1995
- Hulskamp, M.; Schneitz, K.; Pruitt, R. E.
- The Plant Cell
Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools ? associations with asthma and respiratory symptoms in pupils
journal, April 2007
- Kim, J. L.; Elfman, L.; Mi, Y.
- Indoor Air, Vol. 17, Issue 2
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.
journal, December 1995
- Bendelac, A.
- Journal of Experimental Medicine, Vol. 182, Issue 6
Monocyte-Derived CD1a + and CD1a − Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentiation
journal, October 2000
- Chang, Chia-Chun J.; Wright, Anne; Punnonen, Juha
- The Journal of Immunology, Vol. 165, Issue 7
Behavior of storage lipids during development and germination of olive (Olea europaea L.) pollen
journal, June 2003
- Rodríguez-García, M. I.; M'rani-Alaoui, M.; Fernández, M. C.
- Protoplasma, Vol. 221, Issue 3
Links between Pollen, Atopy and the Asthma Epidemic
journal, January 2007
- Taylor, Philip E.; Jacobson, Kraig W.; House, James M.
- International Archives of Allergy and Immunology, Vol. 144, Issue 2
Peroxisome proliferator activated receptor-γ modulates reactive oxygen species generation and activation of nuclear factor-κB and hypoxia-inducible factor 1α in allergic airway disease of mice
journal, July 2006
- Lee, Kyung Sun; Kim, So Ri; Park, Seoung Ju
- Journal of Allergy and Clinical Immunology, Vol. 118, Issue 1
A Study of Phospholipids and Galactolipids in Pollen of Two Lines of Brassica napus L. (Rapeseed) with Different Ratios of Linoleic to Linolenic Acid
journal, June 1990
- Evans, D. Evan; Sang, Joseph P.; Cominos, Xenophon
- Plant Physiology, Vol. 93, Issue 2
Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis)
journal, August 1988
- Gafner, Frank; Epstein, William; Reynolds, Gary
- Contact Dermatitis, Vol. 19, Issue 2
Biological And Health Effects Of Exposure To Kerosene-Based Jet Fuels And Performance Additives
journal, January 2003
- Ritchie, Glenn; Still, Kenneth; Rossi III, John
- Journal of Toxicology and Environmental Health, Part B, Vol. 6, Issue 4
Immunological and Biological Properties of Bet v 4, a Novel Birch Pollen Allergen with Two EF-hand Calcium-binding Domains
journal, November 1997
- Engel, Edwin; Richter, Klaus; Obermeyer, Gerhard
- Journal of Biological Chemistry, Vol. 272, Issue 45
Alterations in CER6, a Gene Identical to CUT1, Differentially Affect Long-Chain Lipid Content on the Surface of Pollen and Stems
journal, October 2000
- Fiebig, Aretha; Mayfield, Jacob A.; Miley, Natasha L.
- The Plant Cell, Vol. 12, Issue 10
Transcription Factors in Asthma: Are Transcription Factors a New Target for Asthma Therapy?
journal, May 2006
- Roth, M.; Black, J.
- Current Drug Targets, Vol. 7, Issue 5
A conditional sterile mutation eliminates surface components from Arabidopsis pollen and disrupts cell signaling during fertilization.
journal, June 1993
- Preuss, D.; Lemieux, B.; Yen, G.
- Genes & Development, Vol. 7, Issue 6
Molecular Characterization of Polygalacturonases as Grass Pollen-Specific Marker Allergens: Expulsion from Pollen via Submicronic Respirable Particles
journal, May 2004
- Swoboda, Ines; Grote, Monika; Verdino, Petra
- The Journal of Immunology, Vol. 172, Issue 10
PPARG Locus Haplotype Variation and Exacerbations in Asthma
journal, February 2007
- Palmer, C. N. A.; Doney, A. S. F.; Ismail, T.
- Clinical Pharmacology & Therapeutics, Vol. 81, Issue 5
Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany
journal, January 2007
- Beck, J.; Heutelbeck, A.; Dunkelberg, H.
- Science of The Total Environment, Vol. 372, Issue 2-3
Lipids are required for directional pollen-tube growth
journal, April 1998
- Wolters-Arts, Mieke; Lush, W. Mary; Mariani, Celestina
- Nature, Vol. 392, Issue 6678
Human CD1-restricted T cell recognition of lipids from pollens
journal, July 2005
- Agea, Elisabetta; Russano, Anna; Bistoni, Onelia
- Journal of Experimental Medicine, Vol. 202, Issue 2
Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted γδ T cells
journal, May 2006
- Russano, Anna M.; Agea, Elisabetta; Corazzi, Lanfranco
- Journal of Allergy and Clinical Immunology, Vol. 117, Issue 5
Gene Families from the
Arabidopsis thaliana
Pollen Coat Proteome
journal, June 2001
- Mayfield, Jacob A.; Fiebig, Aretha; Johnstone, Sarah E.
- Science, Vol. 292, Issue 5526
Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine
journal, June 2004
- Kuroda, Yoshiki; Nacionales, Dina C.; Akaogi, Jun
- Biomedicine & Pharmacotherapy, Vol. 58, Issue 5
Palmitate Activates the NF-κB Transcription Factor and Induces IL-6 and TNFα Expression in 3T3-L1 Adipocytes
journal, August 2005
- Ajuwon, Kolapo M.; Spurlock, Michel E.
- The Journal of Nutrition, Vol. 135, Issue 8
Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization
journal, February 2005
- Traidl-Hoffmann, Claudia; Mariani, Valentina; Hochrein, Hubertus
- Journal of Experimental Medicine, Vol. 201, Issue 4
Impact of Pollen on Human Health: More Than Allergen Carriers?
journal, January 2003
- Traidl-Hoffmann, Claudia; Kasche, Anna; Menzel, Annette
- International Archives of Allergy and Immunology, Vol. 131, Issue 1
Comparison of the contact allergenicity of the four pentadecylcatechols derived from poison ivy urushiol in human subjects
journal, January 1972
- Johnson, Richard A.; Baer, Harold; Kirkpatrick, Charles H.
- Journal of Allergy and Clinical Immunology, Vol. 49, Issue 1
Dual Function of Novel Pollen Coat (Surface) Proteins: IgE-binding Capacity and Proteolytic Activity Disrupting the Airway Epithelial Barrier
journal, January 2013
- Bashir, Mohamed Elfatih H.; Ward, Jason M.; Cummings, Matthew
- PLoS ONE, Vol. 8, Issue 1
Activation of PPARγ Specifies a Dendritic Cell Subtype Capable of Enhanced Induction of iNKT Cell Expansion
journal, July 2004
- Szatmari, Istvan; Gogolak, Peter; Im, Jin Seol
- Immunity, Vol. 21, Issue 1
Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice
journal, February 2006
- Kuroda, Y.; Ono, N.; Akaogi, J.
- Toxicology, Vol. 218, Issue 2-3
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
journal, September 2007
- Joshi-Barve, Swati; Barve, Shirish S.; Amancherla, Kiranmayi
- Hepatology, Vol. 46, Issue 3
Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes
journal, May 2002
- Traidl-Hoffmann, Claudia; Kasche, Anna; Jakob, Thilo
- Journal of Allergy and Clinical Immunology, Vol. 109, Issue 5
Adjuvanticity and Inflammatory Response Following Administration of Water-in-Oil Emulsions Prepared with Saturated Hydrocarbons in Chickens.
journal, January 2000
- Fukanoki, Shin-ichi; Matsumoto, Kohei; Mori, Hajime
- Journal of Veterinary Medical Science, Vol. 62, Issue 8
The Effects of Temperature and Oleic Acid on Murine Memory and Virgin T Cell Activation: Interleukin-2 Secretion and Interleukin-2 Receptor Expression
journal, November 1993
- Wooten, R. Mark; Clem, L. William; Bly, Jan E.
- Cellular Immunology, Vol. 152, Issue 1
Behavior of storage lipids during development and germination of olive (Olea europaea L.) pollen
journal, June 2003
- Rodríguez-García, M. I.; M'rani-Alaoui, M.; Fernández, M. C.
- Protoplasma, Vol. 221, Issue 3
Fatty acid requirement of B lymphocytes activated in vitro
journal, January 1990
- Lernhardt, Waldemar
- Biochemical and Biophysical Research Communications, Vol. 166, Issue 2
Palmitic acid induces IP-10 expression in human macrophages via NF-κB activation
journal, June 2007
- Laine, Phyllis S.; Schwartz, Eric A.; Wang, Yingjie
- Biochemical and Biophysical Research Communications, Vol. 358, Issue 1
Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine
journal, June 2004
- Kuroda, Yoshiki; Nacionales, Dina C.; Akaogi, Jun
- Biomedicine & Pharmacotherapy, Vol. 58, Issue 5
Gas-particle concentration and distribution of n-alkanes and polycyclic aromatic hydrocarbons in the atmosphere of Prato (Italy)
journal, June 2007
- Cincinelli, Alessandra; Bubba, Massimo Del; Martellini, Tania
- Chemosphere, Vol. 68, Issue 3
Activation of PPARγ Specifies a Dendritic Cell Subtype Capable of Enhanced Induction of iNKT Cell Expansion
journal, July 2004
- Szatmari, Istvan; Gogolak, Peter; Im, Jin Seol
- Immunity, Vol. 21, Issue 1
Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted γδ T cells
journal, May 2006
- Russano, Anna M.; Agea, Elisabetta; Corazzi, Lanfranco
- Journal of Allergy and Clinical Immunology, Vol. 117, Issue 5
Peroxisome proliferator activated receptor-γ modulates reactive oxygen species generation and activation of nuclear factor-κB and hypoxia-inducible factor 1α in allergic airway disease of mice
journal, July 2006
- Lee, Kyung Sun; Kim, So Ri; Park, Seoung Ju
- Journal of Allergy and Clinical Immunology, Vol. 118, Issue 1
Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany
journal, January 2007
- Beck, J.; Heutelbeck, A.; Dunkelberg, H.
- Science of The Total Environment, Vol. 372, Issue 2-3
Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice
journal, February 2006
- Kuroda, Y.; Ono, N.; Akaogi, J.
- Toxicology, Vol. 218, Issue 2-3
Linoleic acid is a potent activator of protein kinase C type III- α isoform in pancreatic acinar cells; its role in amylase secretion
journal, May 1988
- Wooten, Marie W.; Wrenn, Robert W.
- Biochemical and Biophysical Research Communications, Vol. 153, Issue 1
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
journal, February 1999
- Lutz, Manfred B.; Kukutsch, Nicole; Ogilvie, Alexandra L. J.
- Journal of Immunological Methods, Vol. 223, Issue 1
Lipids are required for directional pollen-tube growth
journal, April 1998
- Wolters-Arts, Mieke; Lush, W. Mary; Mariani, Celestina
- Nature, Vol. 392, Issue 6678
Rapid initiation of Arabidopsis pollination requires the oleosin-domain protein GRP17
journal, January 2000
- Mayfield, Jacob A.; Preuss, Daphne
- Nature Cell Biology, Vol. 2, Issue 2
Regulation of immunity by self-reactive T cells
journal, June 2005
- Kronenberg, Mitchell; Rudensky, Alexander
- Nature, Vol. 435, Issue 7042
PPARG Locus Haplotype Variation and Exacerbations in Asthma
journal, February 2007
- Palmer, C. N. A.; Doney, A. S. F.; Ismail, T.
- Clinical Pharmacology & Therapeutics, Vol. 81, Issue 5
Identification of volatile organic compounds emitted in the field by oilseed rape (Brassica napusssp.oleifera) over the growing season
journal, March 1998
- Mcewan,
- Clinical & Experimental Allergy, Vol. 28, Issue 3
Intra- and extracellular lipid composition and associated gene expression patterns during pollen development in Brassica napus
journal, March 1997
- Piffanelli, Pietro; Ross, Joanne H. E.; Murphy, Denis J.
- The Plant Journal, Vol. 11, Issue 3
Constituents of the tapetosomes and elaioplasts inBrassica campestristapetum and their degradation and retention during microsporogenesis
journal, December 1998
- Ting, Julie T. L.; Wu, Sherry S. H.; Ratnayake, Chandra
- The Plant Journal, Vol. 16, Issue 5
Biological And Health Effects Of Exposure To Kerosene-Based Jet Fuels And Performance Additives
journal, January 2003
- Ritchie, Glenn; Still, Kenneth; Rossi III, John
- Journal of Toxicology and Environmental Health, Part B, Vol. 6, Issue 4
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.
journal, December 1995
- Bendelac, A.
- Journal of Experimental Medicine, Vol. 182, Issue 6
Palmitate Activates the NF-κB Transcription Factor and Induces IL-6 and TNFα Expression in 3T3-L1 Adipocytes
journal, August 2005
- Ajuwon, Kolapo M.; Spurlock, Michel E.
- The Journal of Nutrition, Vol. 135, Issue 8
Nutrients, Nuclear Receptors, Inflammation, Immunity Lipids, PPAR, and Allergic Asthma
journal, March 2006
- August, Avery; Mueller, Cynthia; Weaver, Veronika
- The Journal of Nutrition, Vol. 136, Issue 3
A conditional sterile mutation eliminates surface components from Arabidopsis pollen and disrupts cell signaling during fertilization.
journal, June 1993
- Preuss, D.; Lemieux, B.; Yen, G.
- Genes & Development, Vol. 7, Issue 6
Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis)
journal, August 1988
- Gafner, Frank; Epstein, William; Reynolds, Gary
- Contact Dermatitis, Vol. 19, Issue 2
Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools ? associations with asthma and respiratory symptoms in pupils
journal, April 2007
- Kim, J. L.; Elfman, L.; Mi, Y.
- Indoor Air, Vol. 17, Issue 2
Gene Families from the
Arabidopsis thaliana
Pollen Coat Proteome
journal, June 2001
- Mayfield, Jacob A.; Fiebig, Aretha; Johnstone, Sarah E.
- Science, Vol. 292, Issue 5526
Links between Pollen, Atopy and the Asthma Epidemic
journal, January 2007
- Taylor, Philip E.; Jacobson, Kraig W.; House, James M.
- International Archives of Allergy and Immunology, Vol. 144, Issue 2
Adjuvanticity and Inflammatory Response Following Administration of Water-in-Oil Emulsions Prepared with Saturated Hydrocarbons in Chickens.
journal, January 2000
- Fukanoki, Shin-ichi; Matsumoto, Kohei; Mori, Hajime
- Journal of Veterinary Medical Science, Vol. 62, Issue 8
Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab)
journal, January 2006
- D??Amato, Gennaro; Bucchioni, Enrica; Oldani, Virginio
- Treatments in Respiratory Medicine, Vol. 5, Issue 6
Transcription Factors in Asthma: Are Transcription Factors a New Target for Asthma Therapy?
journal, May 2006
- Roth, M.; Black, J.
- Current Drug Targets, Vol. 7, Issue 5
Genetic Evidence for a Long-Range Activity That Directs Pollen Tube Guidance in Arabidopsis
journal, January 1995
- Hulskamp, Martin; Schneitz, Kay; Pruitt, Robert E.
- The Plant Cell, Vol. 7, Issue 1
The burden of allergic rhinitis
journal, January 2007
- Nathan, Robert A.
- Allergy and Asthma Proceedings, Vol. 28, Issue 1
Molecular Characterization of Polygalacturonases as Grass Pollen-Specific Marker Allergens: Expulsion from Pollen via Submicronic Respirable Particles
journal, May 2004
- Swoboda, Ines; Grote, Monika; Verdino, Petra
- The Journal of Immunology, Vol. 172, Issue 10
Works referencing / citing this record:
Analysis of morphological and molecular composition changes in allergenic Artemisia vulgaris L. pollen under traffic pollution using SEM and FTIR spectroscopy
journal, September 2016
- Depciuch, J.; Kasprzyk, I.; Roga, E.
- Environmental Science and Pollution Research, Vol. 23, Issue 22
Do lipids influence the allergic sensitization process?
journal, September 2014
- Bublin, Merima; Eiwegger, Thomas; Breiteneder, Heimo
- Journal of Allergy and Clinical Immunology, Vol. 134, Issue 3
Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model
journal, March 2015
- Nambiar, Jonathan; Clarke, Adam W.; Shim, Doris
- mAbs, Vol. 7, Issue 3
A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity
journal, January 2015
- Sénéchal, Hélène; Visez, Nicolas; Charpin, Denis
- The Scientific World Journal, Vol. 2015
Pollen Lipids Can Play a Role in Allergic Airway Inflammation
journal, December 2018
- Dahl, Åslög
- Frontiers in Immunology, Vol. 9
Modulation of Mast Cell Reactivity by Lipids: The Neglected Side of Allergic Diseases
journal, May 2019
- Hagemann, Philipp M.; Nsiah-Dosu, Stephanie; Hundt, Jennifer Elisabeth
- Frontiers in Immunology, Vol. 10
Effects of NO2 and Ozone on Pollen Allergenicity
journal, February 2016
- Frank, Ulrike; Ernst, Dieter
- Frontiers in Plant Science, Vol. 7
The Role of Lipids in Development of Allergic Responses
journal, January 2017
- del Moral, Manuel Gómez; Martínez-Naves, Eduardo
- Immune Network, Vol. 17, Issue 3