Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts
Abstract
Here, we report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.
- Authors:
-
- Chang Gung Memorial Hospital, New Taipei City (Taiwan); National Tsing Hua University, Hsinchu (Taiwan)
- National Yang Ming Chiao Tung University, Hsinchu (Taiwan)
- University of Tennessee, Knoxville, TN (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Chang Gung Memorial Hospital, Yunlin (Taiwan)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- University of Tennessee, Knoxville, TN (United States)
- National Yang Ming Chiao Tung University, Hsinchu (Taiwan); National Taiwan University, Taipei (Taiwan)
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); Ministry of Science and Technology of Taiwan; Chang Gung Medical Foundation; National Yang Ming Chiao Tung University (NYCU); Ministry of Education (MOE) Taiwan; National Science Foundation (NSF); US Army Research Office
- OSTI Identifier:
- 1888905
- Grant/Contract Number:
- AC05-00OR22725; MOST-110-2636-M-009-008; CMRPG3J1131; CMRPVVK0141; DMR-1611180; DMR-1809640; W(11NF-13-1-0438; W911NF-19-2-0049
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Applied Bio Materials
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 2; Journal ID: ISSN 2576-6422
- Publisher:
- ACS Publications
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; biomedical material; NbTaTiVZr; surface modification; in vitro test; biocompatibility
Citation Formats
Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., and Chou, Yi-Chia. Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts. United States: N. p., 2022.
Web. doi:10.1021/acsabm.1c01103.
Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., & Chou, Yi-Chia. Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts. United States. https://doi.org/10.1021/acsabm.1c01103
Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., and Chou, Yi-Chia. Wed .
"Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts". United States. https://doi.org/10.1021/acsabm.1c01103. https://www.osti.gov/servlets/purl/1888905.
@article{osti_1888905,
title = {Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts},
author = {Lin, Shih-Jie and Lin, Jia-An and Yu, Wei and Lee, Chanho and Hung, Chun-Yu and Poplawsky, Jonathan D. and Liaw, Peter K. and Chou, Yi-Chia},
abstractNote = {Here, we report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.},
doi = {10.1021/acsabm.1c01103},
journal = {ACS Applied Bio Materials},
number = 2,
volume = 5,
place = {United States},
year = {Wed Jan 26 00:00:00 EST 2022},
month = {Wed Jan 26 00:00:00 EST 2022}
}
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