Biopolymers and supramolecular polymers as biomaterials for biomedical applications
Abstract
Protein- and peptide-based structural biopolymers are abundant building blocks of biological systems. Either in their natural forms, such as collagen, silk or fibronectin, or as related synthetic materials they can be used in various technologies. An emerging area is that of biomimetic materials inspired by protein-based biopolymers, which are made up of small molecules rather than macromolecules and can therefore be described as supramolecular polymers. These materials are very useful in biomedical applications because of their ability to imitate the extracellular matrix both in architecture and their capacity to signal cells. This article describes important features of the natural extracellular matrix and highlight how these features are being incorporated into biomaterials composed of biopolymers and supramolecular polymers. Here, we particularly focus on the structures, properties, and functions of collagen, fibronectin, silk, and the supramolecular polymers inspired by them as biomaterials for regenerative medicine.
- Authors:
-
- Northwestern Univ., Chicago, IL (United States). Simpson Querrey Institute of BioNanotechnology
- Air Force Institute of Technology, Wright-Patterson AFB, OH (United States)
- Northwestern Univ., Chicago, IL (United States). Simpson Querrey Institute of BioNanotechnology; Northwestern Univ., Evanston, IL (United States)
- Publication Date:
- Research Org.:
- Northwestern Univ., Evanston, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); National Institutes of Health (NIH)
- OSTI Identifier:
- 1820396
- Grant/Contract Number:
- FG02-00ER45810; SC0000989; DMR-1006713-004; 3R01EB003806-09S1; 5R01HL116577-02; 5P01HL108795-04; 5R01DE015920-09
- Resource Type:
- Accepted Manuscript
- Journal Name:
- MRS Bulletin
- Additional Journal Information:
- Journal Volume: 40; Journal Issue: 12; Journal ID: ISSN 0883-7694
- Publisher:
- Materials Research Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; self-assembly; biomedical; biomimetic (assembly); nanostructure
Citation Formats
Freeman, Ronit, Boekhoven, Job, Dickerson, Matthew B., Naik, Rajesh R., and Stupp, Samuel I. Biopolymers and supramolecular polymers as biomaterials for biomedical applications. United States: N. p., 2015.
Web. doi:10.1557/mrs.2015.270.
Freeman, Ronit, Boekhoven, Job, Dickerson, Matthew B., Naik, Rajesh R., & Stupp, Samuel I. Biopolymers and supramolecular polymers as biomaterials for biomedical applications. United States. https://doi.org/10.1557/mrs.2015.270
Freeman, Ronit, Boekhoven, Job, Dickerson, Matthew B., Naik, Rajesh R., and Stupp, Samuel I. Fri .
"Biopolymers and supramolecular polymers as biomaterials for biomedical applications". United States. https://doi.org/10.1557/mrs.2015.270. https://www.osti.gov/servlets/purl/1820396.
@article{osti_1820396,
title = {Biopolymers and supramolecular polymers as biomaterials for biomedical applications},
author = {Freeman, Ronit and Boekhoven, Job and Dickerson, Matthew B. and Naik, Rajesh R. and Stupp, Samuel I.},
abstractNote = {Protein- and peptide-based structural biopolymers are abundant building blocks of biological systems. Either in their natural forms, such as collagen, silk or fibronectin, or as related synthetic materials they can be used in various technologies. An emerging area is that of biomimetic materials inspired by protein-based biopolymers, which are made up of small molecules rather than macromolecules and can therefore be described as supramolecular polymers. These materials are very useful in biomedical applications because of their ability to imitate the extracellular matrix both in architecture and their capacity to signal cells. This article describes important features of the natural extracellular matrix and highlight how these features are being incorporated into biomaterials composed of biopolymers and supramolecular polymers. Here, we particularly focus on the structures, properties, and functions of collagen, fibronectin, silk, and the supramolecular polymers inspired by them as biomaterials for regenerative medicine.},
doi = {10.1557/mrs.2015.270},
journal = {MRS Bulletin},
number = 12,
volume = 40,
place = {United States},
year = {Fri Nov 27 00:00:00 EST 2015},
month = {Fri Nov 27 00:00:00 EST 2015}
}
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