Biomedical Integration of Metal–Organic Frameworks
Abstract
Metal–organic frameworks (MOFs) have recently been demonstrated to be excellent platforms for biomedical applications. On account of their porous nature and modular structure, MOFs have served as bioactive-compound carriers, cell-imaging materials, and therapeutic agents. MOF cavities allow the encapsulation of a variety of guest molecules, facilitating controllable drug release and optical imaging. The metal components of MOFs make them suitable for magnetic resonance imaging (MRI) and computed tomography (CT). Further, MOF-embedded therapeutic agents have demonstrated promise in photodynamic and photothermal therapies. In this review, we describe several advanced examples that utilize MOFs in these cutting-edge applications. Investigation of the relationship between their structure and designated application will enable future, informed exploration of MOFs for biomedical applications.
- Publication Date:
- Research Org.:
- Texas A & M Univ., College Station, TX (United States); Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE Office of Fossil Energy (FE)
- OSTI Identifier:
- 1799851
- Alternate Identifier(s):
- OSTI ID: 1703092
- Grant/Contract Number:
- FE0026472; SC0001015; 1632486
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Trends in Chemistry
- Additional Journal Information:
- Journal Volume: 2; Journal Issue: 5; Journal ID: ISSN 2589-5974
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; chemistry; metal–organic frameworks; biological guest encapsulation; photodynamic therapy; photothermal therapy; drug delivery; bioimaging
Citation Formats
Banerjee, Sayan, Lollar, Christina T., Xiao, Zhifeng, Fang, Yu, and Zhou, Hong-Cai. Biomedical Integration of Metal–Organic Frameworks. United States: N. p., 2020.
Web. doi:10.1016/j.trechm.2020.01.007.
Banerjee, Sayan, Lollar, Christina T., Xiao, Zhifeng, Fang, Yu, & Zhou, Hong-Cai. Biomedical Integration of Metal–Organic Frameworks. United States. https://doi.org/10.1016/j.trechm.2020.01.007
Banerjee, Sayan, Lollar, Christina T., Xiao, Zhifeng, Fang, Yu, and Zhou, Hong-Cai. Wed .
"Biomedical Integration of Metal–Organic Frameworks". United States. https://doi.org/10.1016/j.trechm.2020.01.007. https://www.osti.gov/servlets/purl/1799851.
@article{osti_1799851,
title = {Biomedical Integration of Metal–Organic Frameworks},
author = {Banerjee, Sayan and Lollar, Christina T. and Xiao, Zhifeng and Fang, Yu and Zhou, Hong-Cai},
abstractNote = {Metal–organic frameworks (MOFs) have recently been demonstrated to be excellent platforms for biomedical applications. On account of their porous nature and modular structure, MOFs have served as bioactive-compound carriers, cell-imaging materials, and therapeutic agents. MOF cavities allow the encapsulation of a variety of guest molecules, facilitating controllable drug release and optical imaging. The metal components of MOFs make them suitable for magnetic resonance imaging (MRI) and computed tomography (CT). Further, MOF-embedded therapeutic agents have demonstrated promise in photodynamic and photothermal therapies. In this review, we describe several advanced examples that utilize MOFs in these cutting-edge applications. Investigation of the relationship between their structure and designated application will enable future, informed exploration of MOFs for biomedical applications.},
doi = {10.1016/j.trechm.2020.01.007},
journal = {Trends in Chemistry},
number = 5,
volume = 2,
place = {United States},
year = {Wed Apr 22 00:00:00 EDT 2020},
month = {Wed Apr 22 00:00:00 EDT 2020}
}
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