Cryogenic “Iodide-Tagging” Photoelectron Spectroscopy: A Sensitive Probe for Specific Binding Sites of Amino Acids
Abstract
This work showcases cryogenic and temperature-dependent “iodide-tagging” photoelectron spectroscopy to probe specific binding sites of amino acids using the glycine-iodide complex (Gly?I-) as a case study. Multiple Gly?I- isomers were generated from ambient electrospray ionization and kinetically isolated in a cryogenic ion trap. These structures were characterized with temperature-dependent “iodide-tagging” negative ion photoelectron spectroscopy (NIPES) where iodide was used as the “messenger” to interpret electronic energetics and structural information of various Gly?I- isomers. Accompanied by theoretical computations and Franck-Condon simulations, a total of five cluster structures have been identified along with their various binding motifs. This work demonstrates that “iodide-tagging” NIPES is a powerful general means for probing specific binding interactions in biological molecules of interest.
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Science and Technology of China, Hefei (China)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Hefei Univ. of Technology (China)
- Univ. of Minnesota, Minneapolis, MN (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1639918
- Report Number(s):
- PNNL-SA-152646
Journal ID: ISSN 1948-7185;1948-7185
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Physical Chemistry Letters
- Additional Journal Information:
- Journal Volume: 11; Journal Issue: 11; Journal ID: ISSN 1948-7185
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Zhang, Hanhui, Cao, Wenjin, Yuan, Qinqin, Zhou, Xiaoguo, Valiev, Marat, Kass, Steven R., and Wang, Xue-Bin. Cryogenic “Iodide-Tagging” Photoelectron Spectroscopy: A Sensitive Probe for Specific Binding Sites of Amino Acids. United States: N. p., 2020.
Web. doi:10.1021/acs.jpclett.0c01099.
Zhang, Hanhui, Cao, Wenjin, Yuan, Qinqin, Zhou, Xiaoguo, Valiev, Marat, Kass, Steven R., & Wang, Xue-Bin. Cryogenic “Iodide-Tagging” Photoelectron Spectroscopy: A Sensitive Probe for Specific Binding Sites of Amino Acids. United States. https://doi.org/10.1021/acs.jpclett.0c01099
Zhang, Hanhui, Cao, Wenjin, Yuan, Qinqin, Zhou, Xiaoguo, Valiev, Marat, Kass, Steven R., and Wang, Xue-Bin. Wed .
"Cryogenic “Iodide-Tagging” Photoelectron Spectroscopy: A Sensitive Probe for Specific Binding Sites of Amino Acids". United States. https://doi.org/10.1021/acs.jpclett.0c01099. https://www.osti.gov/servlets/purl/1639918.
@article{osti_1639918,
title = {Cryogenic “Iodide-Tagging” Photoelectron Spectroscopy: A Sensitive Probe for Specific Binding Sites of Amino Acids},
author = {Zhang, Hanhui and Cao, Wenjin and Yuan, Qinqin and Zhou, Xiaoguo and Valiev, Marat and Kass, Steven R. and Wang, Xue-Bin},
abstractNote = {This work showcases cryogenic and temperature-dependent “iodide-tagging” photoelectron spectroscopy to probe specific binding sites of amino acids using the glycine-iodide complex (Gly?I-) as a case study. Multiple Gly?I- isomers were generated from ambient electrospray ionization and kinetically isolated in a cryogenic ion trap. These structures were characterized with temperature-dependent “iodide-tagging” negative ion photoelectron spectroscopy (NIPES) where iodide was used as the “messenger” to interpret electronic energetics and structural information of various Gly?I- isomers. Accompanied by theoretical computations and Franck-Condon simulations, a total of five cluster structures have been identified along with their various binding motifs. This work demonstrates that “iodide-tagging” NIPES is a powerful general means for probing specific binding interactions in biological molecules of interest.},
doi = {10.1021/acs.jpclett.0c01099},
journal = {Journal of Physical Chemistry Letters},
number = 11,
volume = 11,
place = {United States},
year = {Wed May 13 00:00:00 EDT 2020},
month = {Wed May 13 00:00:00 EDT 2020}
}
Web of Science
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