Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy
Abstract
To examine the effects of Roux-en-Y gastric bypass (RYGB) surgery with and without laparoscopic removal of omental fat (omentectomy) on the temporal gene expression profiles of skeletal muscle. Previously reported were the whole-body metabolic effects of a randomized, single-blinded study in patients receiving RYGB surgery stratified to receive or not receive omentectomy. In this follow up study we report on changes in skeletal muscle gene expression in a subset of 21 patients, for whom biopsies were collected preoperatively and at either 6 months or 12 months postoperatively. RNA isolated from skeletal muscle biopsies of 21 subjects (8 without omentectomy and 13 with omentectomy) taken before RYGB or at 6 and 12 months postoperatively were subjected to gene expression profiling via Exon 1.0 S/T Array and Taqman Low Density Array. Robust Multichip Analysis and gene enrichment data analysis revealed 84 genes with at least a 4-fold expression difference after surgery. At 6 and 12 months the RYGB with omentectomy group displayed a greater reduction in the expression of genes associated with skeletal muscle inflammation (ANKRD1, CDR1, CH25H, CXCL2, CX3CR1, IL8, LBP, NFIL3, SELE, SOCS3, TNFAIP3, and ZFP36) relative to the RYGB nonomentectomy group. Expressions of IL6 and CCL2 were decreased atmore »
- Authors:
-
- Vanderbilt University, Nashville, TN (United States)
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); Vanderbilt Ingram Cancer Center; Vanderbilt Digestive Disease Center; Vanderbilt Vision Center; National Institutes of Health (NIH); Vanderbilt Clinical and Translational Science Award; Vanderbilt Diabetes Research and Training Center; Vanderbilt Digestive Disease Research Center
- OSTI Identifier:
- 1627487
- Grant/Contract Number:
- AC02-05CH11231; P30 CA68485; P30 DK58404; P30 EY08126; R01 DK70860 to NNA; UL1 RR024975; P30 DK020593; P30 DK058404
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 12; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; small nucleolar RNA; skeletal muscles; inflammation; transcription factors; gene expression; extracellular matrix proteins; microarrays; transcriptional control
Citation Formats
Tamboli, Robyn A., Hajri, Tahar, Jiang, Aixiang, Marks-Shulman, Pamela A., Williams, D. Brandon, Clements, Ronald H., Melvin, Willie, Bowen, Benjamin P., Shyr, Yu, Abumrad, Naji N., and Flynn, Charles Robb. Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy. United States: N. p., 2011.
Web. doi:10.1371/journal.pone.0028577.
Tamboli, Robyn A., Hajri, Tahar, Jiang, Aixiang, Marks-Shulman, Pamela A., Williams, D. Brandon, Clements, Ronald H., Melvin, Willie, Bowen, Benjamin P., Shyr, Yu, Abumrad, Naji N., & Flynn, Charles Robb. Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy. United States. https://doi.org/10.1371/journal.pone.0028577
Tamboli, Robyn A., Hajri, Tahar, Jiang, Aixiang, Marks-Shulman, Pamela A., Williams, D. Brandon, Clements, Ronald H., Melvin, Willie, Bowen, Benjamin P., Shyr, Yu, Abumrad, Naji N., and Flynn, Charles Robb. Fri .
"Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy". United States. https://doi.org/10.1371/journal.pone.0028577. https://www.osti.gov/servlets/purl/1627487.
@article{osti_1627487,
title = {Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy},
author = {Tamboli, Robyn A. and Hajri, Tahar and Jiang, Aixiang and Marks-Shulman, Pamela A. and Williams, D. Brandon and Clements, Ronald H. and Melvin, Willie and Bowen, Benjamin P. and Shyr, Yu and Abumrad, Naji N. and Flynn, Charles Robb},
abstractNote = {To examine the effects of Roux-en-Y gastric bypass (RYGB) surgery with and without laparoscopic removal of omental fat (omentectomy) on the temporal gene expression profiles of skeletal muscle. Previously reported were the whole-body metabolic effects of a randomized, single-blinded study in patients receiving RYGB surgery stratified to receive or not receive omentectomy. In this follow up study we report on changes in skeletal muscle gene expression in a subset of 21 patients, for whom biopsies were collected preoperatively and at either 6 months or 12 months postoperatively. RNA isolated from skeletal muscle biopsies of 21 subjects (8 without omentectomy and 13 with omentectomy) taken before RYGB or at 6 and 12 months postoperatively were subjected to gene expression profiling via Exon 1.0 S/T Array and Taqman Low Density Array. Robust Multichip Analysis and gene enrichment data analysis revealed 84 genes with at least a 4-fold expression difference after surgery. At 6 and 12 months the RYGB with omentectomy group displayed a greater reduction in the expression of genes associated with skeletal muscle inflammation (ANKRD1, CDR1, CH25H, CXCL2, CX3CR1, IL8, LBP, NFIL3, SELE, SOCS3, TNFAIP3, and ZFP36) relative to the RYGB nonomentectomy group. Expressions of IL6 and CCL2 were decreased at all postoperative time points. There was differential expression of genes driving protein turnover (IGFN1, FBXW10) in both groups over time and increased expression of PAAF1 in the non-omentectomy group at 12 months. Evidence for the activation of skeletal muscle satellite cells was inferred from the up-regulation of HOXC10. The elevated post-operative expression of 22 small nucleolar RNAs and the decreased expression of the transcription factors JUNB, FOS, FOSB, ATF3 MYC, EGR1 as well as the orphan nuclear receptors NR4A1, NR4A2, NR4A3 suggest dramatic reorganizations at both the cellular and genetic levels. These data indicate that RYGB reduces skeletal muscle inflammation, and removal of omental fat further amplifies this response.},
doi = {10.1371/journal.pone.0028577},
journal = {PLoS ONE},
number = 12,
volume = 6,
place = {United States},
year = {Fri Dec 16 00:00:00 EST 2011},
month = {Fri Dec 16 00:00:00 EST 2011}
}
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