ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms
Abstract
Background In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing a causal link between ZIKV infection and birth defects is still a challenge. MicroRNAs (miRNAs) are small noncoding RNAs (sncRNAs) that regulate post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. The potential for flavivirus-mediated miRNA signalling dysfunction in brain-tissue development provides a compelling hypothesis to test the perceived link between ZIKV and microcephaly. Methodology/Principal Findings Here, we applied in silico analyses to provide novel insights to understand how Congenital ZIKA Syndrome symptoms may be related to an imbalance in miRNAs function. Moreover, following World Health Organization (WHO) recommendations, we have assembled a database to help target investigations of the possible relationship between ZIKV symptoms and miRNA-mediated human gene expression. Conclusions/Significance We have computationally predicted both miRNAs encoded by ZIKV able to target genes in the human genome and cellular (human) miRNAs capable of interacting with ZIKV genomes. Our results represent a step forward in the ZIKV studies, providing new insights to support research in this field and identify potential targets for therapy.
- Authors:
-
- René Rachou Research Center (CPqRR-FIOCRUZ), Minas Gerais (Brazil). Biosystems Informatics and Genomics Group
- Univ. of Chicago, IL (United States). Dept. of Ecology and Evolution; Argonne National Lab. (ANL), Argonne, IL (United States). Inst. for Genomic and Systems Biology; Univ. of Chicago, IL (United States). Dept. of Surgery
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1627327
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Neglected Tropical Diseases (Online)
- Additional Journal Information:
- Journal Name: PLoS Neglected Tropical Diseases (Online); Journal Volume: 10; Journal Issue: 6; Journal ID: ISSN 1935-2735
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Infectious Diseases; Parasitology; Tropical Medicine
Citation Formats
Pylro, Victor Satler, Oliveira, Francislon Silva, Morais, Daniel Kumazawa, Cuadros-Orellana, Sara, Pais, Fabiano Sviatopolk-Mirsky, Medeiros, Julliane Dutra, Geraldo, Juliana Assis, Gilbert, Jack, Volpini, Angela Cristina, and Fernandes, Gabriel Rocha. ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms. United States: N. p., 2016.
Web. doi:10.1371/journal.pntd.0004817.
Pylro, Victor Satler, Oliveira, Francislon Silva, Morais, Daniel Kumazawa, Cuadros-Orellana, Sara, Pais, Fabiano Sviatopolk-Mirsky, Medeiros, Julliane Dutra, Geraldo, Juliana Assis, Gilbert, Jack, Volpini, Angela Cristina, & Fernandes, Gabriel Rocha. ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms. United States. https://doi.org/10.1371/journal.pntd.0004817
Pylro, Victor Satler, Oliveira, Francislon Silva, Morais, Daniel Kumazawa, Cuadros-Orellana, Sara, Pais, Fabiano Sviatopolk-Mirsky, Medeiros, Julliane Dutra, Geraldo, Juliana Assis, Gilbert, Jack, Volpini, Angela Cristina, and Fernandes, Gabriel Rocha. Wed .
"ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms". United States. https://doi.org/10.1371/journal.pntd.0004817. https://www.osti.gov/servlets/purl/1627327.
@article{osti_1627327,
title = {ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms},
author = {Pylro, Victor Satler and Oliveira, Francislon Silva and Morais, Daniel Kumazawa and Cuadros-Orellana, Sara and Pais, Fabiano Sviatopolk-Mirsky and Medeiros, Julliane Dutra and Geraldo, Juliana Assis and Gilbert, Jack and Volpini, Angela Cristina and Fernandes, Gabriel Rocha},
abstractNote = {Background In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing a causal link between ZIKV infection and birth defects is still a challenge. MicroRNAs (miRNAs) are small noncoding RNAs (sncRNAs) that regulate post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. The potential for flavivirus-mediated miRNA signalling dysfunction in brain-tissue development provides a compelling hypothesis to test the perceived link between ZIKV and microcephaly. Methodology/Principal Findings Here, we applied in silico analyses to provide novel insights to understand how Congenital ZIKA Syndrome symptoms may be related to an imbalance in miRNAs function. Moreover, following World Health Organization (WHO) recommendations, we have assembled a database to help target investigations of the possible relationship between ZIKV symptoms and miRNA-mediated human gene expression. Conclusions/Significance We have computationally predicted both miRNAs encoded by ZIKV able to target genes in the human genome and cellular (human) miRNAs capable of interacting with ZIKV genomes. Our results represent a step forward in the ZIKV studies, providing new insights to support research in this field and identify potential targets for therapy.},
doi = {10.1371/journal.pntd.0004817},
journal = {PLoS Neglected Tropical Diseases (Online)},
number = 6,
volume = 10,
place = {United States},
year = {Wed Jun 22 00:00:00 EDT 2016},
month = {Wed Jun 22 00:00:00 EDT 2016}
}
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