Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic
Abstract
The development of new image-guided drug delivery tools to improve the therapeutic efficacy of chemotherapeutics remains an important goal in nanomedicine. Using labeling strategies that involve radioelements that have theranostic pairs of diagnostic positron-emitting isotopes and therapeutic electron-emitting isotopes has promise in achieving this goal and further enhancing drug performance through radiotherapeutic effects. The isotopes of radioarsenic offer such theranostic potential and would allow for the use of positron emission tomography (PET) for image-guided drug delivery studies of the arsenic-based chemotherapeutic arsenic trioxide (ATO). Thiolated mesoporous silica nanoparticles (MSN) are shown to effectively and stably bind cyclotron-produced radioarsenic. Labeling studies elucidate that this affinity is a result of specific binding between trivalent arsenic and nanoparticle thiol surface modification. Serial PET imaging of the in vivo murine biodistribution of radiolabeled silica nanoparticles shows very good stability toward dearsenylation that is directly proportional to silica porosity. Thiolated MSNs are found to have a macroscopic arsenic loading capacity of 20 mg of ATO per gram of MSN, sufficient for delivery of chemotherapeutic quantities of the drug. In conclusion, these results show the great potential of radioarsenic-labeled thiolated MSN for the preparation of theranostic radiopharmaceuticals and image-guided drug delivery of ATO-based chemotherapeutics.
- Authors:
-
[1];
- Univ. of Wisconsin, Madison, WI (United States). School of Medicine and Public Health and Dept. of Medical Physics
- Univ. of Wisconsin, Madison, WI (United States). School of Medicine and Public Health and Dept. of Radiology; Memorial Sloan Kettering Cancer Center, New York City, NY (United States)
- Univ. of Wisconsin, Madison, WI (United States). Materials Science Program
- Univ. of Wisconsin, Madison, WI (United States). School of Medicine and Public Health, Dept. of Medical Physics, Dept. of Radiology, Materials Science Program and Carbone Cancer Center
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH); American Cancer Society (ACS)
- OSTI Identifier:
- 1463090
- Grant/Contract Number:
- SC0005281; SC0008384; T32CA009206; 1R0-1CA169365; 125246-RSG-13-099-01-CCE; P30 CA014520
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Applied Materials and Interfaces
- Additional Journal Information:
- Journal Volume: 9; Journal Issue: 8; Journal ID: ISSN 1944-8244
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; 77 NANOSCIENCE AND NANOTECHNOLOGY; arsenic trioxide; As-72; As-76; As-77; image-guided drug delivery; positron emission tomography; radioarsenic; radiolabeling
Citation Formats
Ellison, Paul A., Chen, Feng, Goel, Shreya, Barnhart, Todd E., Nickles, Robert J., DeJesus, Onofre T., and Cai, Weibo. Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic. United States: N. p., 2017.
Web. doi:10.1021/acsami.6b14049.
Ellison, Paul A., Chen, Feng, Goel, Shreya, Barnhart, Todd E., Nickles, Robert J., DeJesus, Onofre T., & Cai, Weibo. Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic. United States. https://doi.org/10.1021/acsami.6b14049
Ellison, Paul A., Chen, Feng, Goel, Shreya, Barnhart, Todd E., Nickles, Robert J., DeJesus, Onofre T., and Cai, Weibo. Mon .
"Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic". United States. https://doi.org/10.1021/acsami.6b14049. https://www.osti.gov/servlets/purl/1463090.
@article{osti_1463090,
title = {Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic},
author = {Ellison, Paul A. and Chen, Feng and Goel, Shreya and Barnhart, Todd E. and Nickles, Robert J. and DeJesus, Onofre T. and Cai, Weibo},
abstractNote = {The development of new image-guided drug delivery tools to improve the therapeutic efficacy of chemotherapeutics remains an important goal in nanomedicine. Using labeling strategies that involve radioelements that have theranostic pairs of diagnostic positron-emitting isotopes and therapeutic electron-emitting isotopes has promise in achieving this goal and further enhancing drug performance through radiotherapeutic effects. The isotopes of radioarsenic offer such theranostic potential and would allow for the use of positron emission tomography (PET) for image-guided drug delivery studies of the arsenic-based chemotherapeutic arsenic trioxide (ATO). Thiolated mesoporous silica nanoparticles (MSN) are shown to effectively and stably bind cyclotron-produced radioarsenic. Labeling studies elucidate that this affinity is a result of specific binding between trivalent arsenic and nanoparticle thiol surface modification. Serial PET imaging of the in vivo murine biodistribution of radiolabeled silica nanoparticles shows very good stability toward dearsenylation that is directly proportional to silica porosity. Thiolated MSNs are found to have a macroscopic arsenic loading capacity of 20 mg of ATO per gram of MSN, sufficient for delivery of chemotherapeutic quantities of the drug. In conclusion, these results show the great potential of radioarsenic-labeled thiolated MSN for the preparation of theranostic radiopharmaceuticals and image-guided drug delivery of ATO-based chemotherapeutics.},
doi = {10.1021/acsami.6b14049},
journal = {ACS Applied Materials and Interfaces},
number = 8,
volume = 9,
place = {United States},
year = {Mon Feb 06 00:00:00 EST 2017},
month = {Mon Feb 06 00:00:00 EST 2017}
}
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