Title: Simultaneous 3D MR elastography of the in vivo mouse brain

Abstract

The feasibility of sample interval modulation (SLIM) magnetic resonance elastography (MRE) for the in vivo mouse brain is assessed, and an alternative SLIM-MRE encoding method is introduced. In SLIMMRE, the phase accumulation for each motion direction is encoded simultaneously by varying either the start time of the motion encoding gradient (MEG), SLIM-phase constant (SLIM-PC), or the initial phase of the MEG, SLIM-phase varying (SLIM-PV). SLIM-PC provides gradient moment nulling, but the mutual gradient shift necessitates increased echo time (TE). SLIM-PV requires no increased TE, but exhibits nonuniform flow compensation. Comparison was to conventional MRE using six C57BL/6 mice. For SLIMPC, the Spearman’s rank correlation to conventional MRE for the shear storage and loss modulus images were 80% and 76%, respectively, and likewise for SLIM-PV, 73% and 69%, respectively. The results of the Wilcoxon rank sum test showed that there were no statistically significant differences between the spatially averaged shear moduli derived from conventional-MRE, SLIM-PC, and SLIM-PV acquisitions. Both SLIM approaches were comparable to conventional MRE scans with Spearman’s rank correlation of 69%-80% and with 3 times reduction in scan time. As a result, the SLIM-PC method had the best correlation, and SLIM-PV may be a useful tool in experimental conditions,more » where both measurement time and T2 relaxation is critical.« less

Authors:

Kearney, Steven P. ^[1]; Majumdar, Shreyan ^[2]; Royston, Thomas J. ^[2]; Klatt, Dieter ^[2]

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+ Show Author Affiliations

1. Univ. of Illinois at Chicago, Chicago, IL (United States); Argonne National Lab. (ANL), Argonne, IL (United States)
2. Univ. of Illinois at Chicago, Chicago, IL (United States)

Publication Date:

Fri Sep 15 00:00:00 EDT 2017

Research Org.:

Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:

Univ. of Illinois at Chicago, Chicago, IL (United States)

OSTI Identifier:

1434246

Grant/Contract Number:  

AC02-06CH11357

Resource Type:

Accepted Manuscript

Journal Name:

Physics in Medicine and Biology (Online)

Additional Journal Information:

Journal Name: Physics in Medicine and Biology (Online); Journal Volume: 62; Journal Issue: 19; Journal ID: ISSN 1361-6560

Publisher:

IOP Publishing

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES; MRE; SLIM; elastography; shear modulus; simultaneous; stiffness