Emerging structural insights into the function of ionotropic glutamate receptors
Abstract
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.
- Authors:
-
- Cold Spring Harbor Laboratory Cold Spring Harbor, NY (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Org.:
- National Institutes of Health (NIH); USDOE
- OSTI Identifier:
- 1352280
- Grant/Contract Number:
- MH085926; GM105730
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Trends in Biochemical Sciences
- Additional Journal Information:
- Journal Volume: 40; Journal Issue: 6; Journal ID: ISSN 0968-0004
- Publisher:
- Cell Press
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; ionotropic glutamate receptors; structural biology; pharmacology
Citation Formats
Karakas, Erkan, Regan, Michael C., and Furukawa, Hiro. Emerging structural insights into the function of ionotropic glutamate receptors. United States: N. p., 2015.
Web. doi:10.1016/j.tibs.2015.04.002.
Karakas, Erkan, Regan, Michael C., & Furukawa, Hiro. Emerging structural insights into the function of ionotropic glutamate receptors. United States. https://doi.org/10.1016/j.tibs.2015.04.002
Karakas, Erkan, Regan, Michael C., and Furukawa, Hiro. Fri .
"Emerging structural insights into the function of ionotropic glutamate receptors". United States. https://doi.org/10.1016/j.tibs.2015.04.002. https://www.osti.gov/servlets/purl/1352280.
@article{osti_1352280,
title = {Emerging structural insights into the function of ionotropic glutamate receptors},
author = {Karakas, Erkan and Regan, Michael C. and Furukawa, Hiro},
abstractNote = {Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.},
doi = {10.1016/j.tibs.2015.04.002},
journal = {Trends in Biochemical Sciences},
number = 6,
volume = 40,
place = {United States},
year = {Fri May 01 00:00:00 EDT 2015},
month = {Fri May 01 00:00:00 EDT 2015}
}
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