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Title: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Abstract

Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3.54). These hotspots may be sites of selective susceptibility to double-strand-break damage due to high transcriptional activity or, through incrementally increasing copy number, may be sites of secondary selective pressure. Furthermore, the transcriptomic consequences ranged from strong individual oncogene effects to weak but quantifiable multigene expression effects. We thus present a somatic-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and contributing a continuum of driver consequences, from modest to strong effects, thereby supporting a polygenic model of cancer development.

Authors:
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Publication Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1341860
Report Number(s):
LA-UR-16-21897
Journal ID: ISSN 1061-4036
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Accepted Manuscript
Journal Name:
Nature Genetics
Additional Journal Information:
Journal Volume: 49; Journal Issue: 3; Journal ID: ISSN 1061-4036
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Biological Science

Citation Formats

Glodzik, Dominik, Morganella, Sandro, Davies, Helen, Simpson, Peter T., Li, Yilong, Zou, Xueqing, Diez-Perez, Javier, Staaf, Johan, Alexandrov, Ludmil B., Smid, Marcel, Brinkman, Arie B., Rye, Inga Hansine, Russnes, Hege, Raine, Keiran, Purdie, Colin A., Lakhani, Sunil R., Thompson, Alastair M., Birney, Ewan, Stunnenberg, Hendrik G., van de Vijver, Marc J., Martens, John W. M., Børresen-Dale, Anne-Lise, Richardson, Andrea L., Kong, Gu, Viari, Alain, Easton, Douglas, Evan, Gerard, Campbell, Peter J., Stratton, Michael R., and Nik-Zainal, Serena. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. United States: N. p., 2017. Web. doi:10.1038/ng.3771.
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Glodzik, Dominik, Morganella, Sandro, Davies, Helen, Simpson, Peter T., Li, Yilong, Zou, Xueqing, Diez-Perez, Javier, Staaf, Johan, Alexandrov, Ludmil B., Smid, Marcel, Brinkman, Arie B., Rye, Inga Hansine, Russnes, Hege, Raine, Keiran, Purdie, Colin A., Lakhani, Sunil R., Thompson, Alastair M., Birney, Ewan, Stunnenberg, Hendrik G., van de Vijver, Marc J., Martens, John W. M., Børresen-Dale, Anne-Lise, Richardson, Andrea L., Kong, Gu, Viari, Alain, Easton, Douglas, Evan, Gerard, Campbell, Peter J., Stratton, Michael R., & Nik-Zainal, Serena. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. United States. https://doi.org/10.1038/ng.3771
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Glodzik, Dominik, Morganella, Sandro, Davies, Helen, Simpson, Peter T., Li, Yilong, Zou, Xueqing, Diez-Perez, Javier, Staaf, Johan, Alexandrov, Ludmil B., Smid, Marcel, Brinkman, Arie B., Rye, Inga Hansine, Russnes, Hege, Raine, Keiran, Purdie, Colin A., Lakhani, Sunil R., Thompson, Alastair M., Birney, Ewan, Stunnenberg, Hendrik G., van de Vijver, Marc J., Martens, John W. M., Børresen-Dale, Anne-Lise, Richardson, Andrea L., Kong, Gu, Viari, Alain, Easton, Douglas, Evan, Gerard, Campbell, Peter J., Stratton, Michael R., and Nik-Zainal, Serena. Mon . "A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers". United States. https://doi.org/10.1038/ng.3771. https://www.osti.gov/servlets/purl/1341860.
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@article{osti_1341860,
title = {A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers},
author = {Glodzik, Dominik and Morganella, Sandro and Davies, Helen and Simpson, Peter T. and Li, Yilong and Zou, Xueqing and Diez-Perez, Javier and Staaf, Johan and Alexandrov, Ludmil B. and Smid, Marcel and Brinkman, Arie B. and Rye, Inga Hansine and Russnes, Hege and Raine, Keiran and Purdie, Colin A. and Lakhani, Sunil R. and Thompson, Alastair M. and Birney, Ewan and Stunnenberg, Hendrik G. and van de Vijver, Marc J. and Martens, John W. M. and Børresen-Dale, Anne-Lise and Richardson, Andrea L. and Kong, Gu and Viari, Alain and Easton, Douglas and Evan, Gerard and Campbell, Peter J. and Stratton, Michael R. and Nik-Zainal, Serena},
abstractNote = {Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3.54). These hotspots may be sites of selective susceptibility to double-strand-break damage due to high transcriptional activity or, through incrementally increasing copy number, may be sites of secondary selective pressure. Furthermore, the transcriptomic consequences ranged from strong individual oncogene effects to weak but quantifiable multigene expression effects. We thus present a somatic-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and contributing a continuum of driver consequences, from modest to strong effects, thereby supporting a polygenic model of cancer development.},
doi = {10.1038/ng.3771},
journal = {Nature Genetics},
number = 3,
volume = 49,
place = {United States},
year = {Mon Jan 23 00:00:00 EST 2017},
month = {Mon Jan 23 00:00:00 EST 2017}
}
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https://doi.org/10.1038/ng.3771
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Works referenced in this record:

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
journal, December 2013

  • Costantino, Lorenzo; Sotiriou, Sotirios K.; Rantala, Juha K.
  • Science, Vol. 343, Issue 6166
  • DOI: 10.1126/science.1243211

Genome-wide association study identifies novel breast cancer susceptibility loci
journal, June 2007

  • Easton, Douglas F.; Pooley, Karen A.; Dunning, Alison M.
  • Nature, Vol. 447, Issue 7148
  • DOI: 10.1038/nature05887

The tandem duplicator phenotype as a distinct genomic configuration in cancer
journal, April 2016

  • Menghi, Francesca; Inaki, Koichiro; Woo, XingYi
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 17
  • DOI: 10.1073/pnas.1520010113

The topography of mutational processes in breast cancer genomes
journal, May 2016

  • Morganella, Sandro; Alexandrov, Ludmil B.; Glodzik, Dominik
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms11383

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
journal, March 2015

  • Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara
  • Nature Genetics, Vol. 47, Issue 4
  • DOI: 10.1038/ng.3242

Signatures of mutational processes in human cancer
journal, August 2013

  • Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C.
  • Nature, Vol. 500, Issue 7463
  • DOI: 10.1038/nature12477

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
journal, September 2012

  • Siddiq, Afshan; Couch, Fergus J.; Chen, Gary K.
  • Human Molecular Genetics, Vol. 21, Issue 24
  • DOI: 10.1093/hmg/dds381

The mini-driver model of polygenic cancer evolution
journal, October 2015

  • Castro-Giner, Francesc; Ratcliffe, Peter; Tomlinson, Ian
  • Nature Reviews Cancer, Vol. 15, Issue 11
  • DOI: 10.1038/nrc3999

Landscape of somatic mutations in 560 breast cancer whole-genome sequences
journal, May 2016

  • Nik-Zainal, Serena; Davies, Helen; Staaf, Johan
  • Nature, Vol. 534, Issue 7605
  • DOI: 10.1038/nature17676

Mechanisms underlying mutational signatures in human cancers
journal, July 2014

  • Helleday, Thomas; Eshtad, Saeed; Nik-Zainal, Serena
  • Nature Reviews Genetics, Vol. 15, Issue 9
  • DOI: 10.1038/nrg3729

Whole–genome characterization of chemoresistant ovarian cancer
journal, May 2015

  • Patch, Ann-Marie; Christie, Elizabeth L.; Etemadmoghadam, Dariush
  • Nature, Vol. 521, Issue 7553
  • DOI: 10.1038/nature14410

A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes
journal, November 2007

  • Easton, Douglas F.; Deffenbaugh, Amie M.; Pruss, Dmitry
  • The American Journal of Human Genetics, Vol. 81, Issue 5
  • DOI: 10.1086/521032

Repair Pathway Choices and Consequences at the Double-Strand Break
journal, January 2016

  • Ceccaldi, Raphael; Rondinelli, Beatrice; D’Andrea, Alan D.
  • Trends in Cell Biology, Vol. 26, Issue 1
  • DOI: 10.1016/j.tcb.2015.07.009

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
journal, November 2013

  • Shi, J.; Whyte, W. A.; Zepeda-Mendoza, C. J.
  • Genes & Development, Vol. 27, Issue 24
  • DOI: 10.1101/gad.232710.113

ENCODE data at the ENCODE portal
journal, November 2015

  • Sloan, Cricket A.; Chan, Esther T.; Davidson, Jean M.
  • Nucleic Acids Research, Vol. 44, Issue D1
  • DOI: 10.1093/nar/gkv1160

Genome-wide association study identifies five new breast cancer susceptibility loci
journal, May 2010

  • Turnbull, Clare; Ahmed, Shahana; Morrison, Jonathan
  • Nature Genetics, Vol. 42, Issue 6
  • DOI: 10.1038/ng.586

Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement
journal, December 2015

An improved method for detecting and delineating genomic regions with altered gene expression in cancer
journal, January 2008

Complex landscapes of somatic rearrangement in human breast cancer genomes
journal, December 2009

  • Stephens, Philip J.; McBride, David J.; Lin, Meng-Lay
  • Nature, Vol. 462, Issue 7276
  • DOI: 10.1038/nature08645

Highly Recurrent TERT Promoter Mutations in Human Melanoma
journal, January 2013

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney
journal, November 2015

  • Roy, Angshumoy; Kumar, Vijetha; Zorman, Barry
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms9891

The Ensembl Regulatory Build
journal, March 2015

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
journal, December 2015

  • Zhang, Xiaoyang; Choi, Peter S.; Francis, Joshua M.
  • Nature Genetics, Vol. 48, Issue 2
  • DOI: 10.1038/ng.3470

Mutational Processes Molding the Genomes of 21 Breast Cancers
journal, May 2012

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes
journal, July 2012

  • McBride, David J.; Etemadmoghadam, Dariush; Cooke, Susanna L.
  • The Journal of Pathology, Vol. 227, Issue 4
  • DOI: 10.1002/path.4042

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
journal, September 2013

Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase
journal, January 2016

  • Wei, Zhiyi; Xu, Zhiwen; Liu, Xiaotian
  • Nucleic Acids Research, Vol. 44, Issue 3
  • DOI: 10.1093/nar/gkw002

Genome-wide association studies identify four ER negative–specific breast cancer risk loci
journal, March 2013

  • Garcia-Closas, Montserrat; Couch, Fergus J.; Lindstrom, Sara
  • Nature Genetics, Vol. 45, Issue 4
  • DOI: 10.1038/ng.2561

Non-coding recurrent mutations in chronic lymphocytic leukaemia
journal, July 2015

  • Puente, Xose S.; Beà, Silvia; Valdés-Mas, Rafael
  • Nature, Vol. 526, Issue 7574
  • DOI: 10.1038/nature14666

Whole genomes redefine the mutational landscape of pancreatic cancer
journal, February 2015

  • Waddell, Nicola; Pajic, Marina; Patch, Ann-Marie
  • Nature, Vol. 518, Issue 7540
  • DOI: 10.1038/nature14169

Migrating bubble during break-induced replication drives conservative DNA synthesis
journal, September 2013

  • Saini, Natalie; Ramakrishnan, Sreejith; Elango, Rajula
  • Nature, Vol. 502, Issue 7471
  • DOI: 10.1038/nature12584

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer
journal, April 2008

  • Stacey, Simon N.; Manolescu, Andrei; Sulem, Patrick
  • Nature Genetics, Vol. 40, Issue 6
  • DOI: 10.1038/ng.131

Activating ESR1 mutations in hormone-resistant metastatic breast cancer
journal, November 2013

  • Robinson, Dan R.; Wu, Yi-Mi; Vats, Pankaj
  • Nature Genetics, Vol. 45, Issue 12
  • DOI: 10.1038/ng.2823

A common coding variant in CASP8 is associated with breast cancer risk
journal, February 2007

  • Cox, Angela; Dunning, Alison M.; Garcia-Closas, Montserrat
  • Nature Genetics, Vol. 39, Issue 3
  • DOI: 10.1038/ng1981

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
journal, March 2009

  • Thomas, Gilles; Jacobs, Kevin B.; Kraft, Peter
  • Nature Genetics, Vol. 41, Issue 5
  • DOI: 10.1038/ng.353

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
journal, March 2009

  • Ahmed, Shahana; Thomas, Gilles; Ghoussaini, Maya
  • Nature Genetics, Vol. 41, Issue 5
  • DOI: 10.1038/ng.354

Modelling Myc inhibition as a cancer therapy
journal, August 2008

  • Soucek, Laura; Whitfield, Jonathan; Martins, Carla P.
  • Nature, Vol. 455, Issue 7213
  • DOI: 10.1038/nature07260

Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
journal, February 2008

Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
journal, January 2012

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
journal, August 2014

Frequency of TERT promoter mutations in human cancers
journal, July 2013

  • Vinagre, João; Almeida, Ana; Pópulo, Helena
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms3185

SEA: a super-enhancer archive
journal, November 2015

  • Wei, Yanjun; Zhang, Shumei; Shang, Shipeng
  • Nucleic Acids Research, Vol. 44, Issue D1
  • DOI: 10.1093/nar/gkv1243

Genome-wide association study identifies novel breast cancer susceptibility loci
journal, January 2008

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
text, January 2012

  • E., Buring, Julie; Kyong, Rhie, Suhn; Angela, Cox,
  • The University of North Carolina at Chapel Hill University Libraries
  • DOI: 10.17615/ydde-fz49

Signatures of mutational processes in human cancer.
text, January 2013

  • Alexandrov, Ludmil B.; Nik-Zainal Abidin, Serena; Wedge, David C.
  • Apollo - University of Cambridge Repository
  • DOI: 10.17863/cam.31889

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
text, January 2013

  • Jin, Zhang,; Rama, Suresh,; Shuying, Liu,
  • The University of North Carolina at Chapel Hill University Libraries
  • DOI: 10.17615/e08j-4t49

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
journalarticle, January 2016

  • Nik-Zainal, Serena; Davies, Helen; Staaf, Johan
  • Springer Science and Business Media LLC
  • DOI: 10.17863/cam.31887

The topography of mutational processes in breast cancer genomes.
text, January 2016

  • Morganella, Sandro; Alexandrov, Ludmil B.; Glodzik, Dominik
  • Apollo - University of Cambridge Repository
  • DOI: 10.17863/cam.31875
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    posted_content, October 2018

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    journal, February 2019

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    • Genome Biology, Vol. 20, Issue 1
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