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Title: In vivo epidermal migration requires focal adhesion targeting of ACF7

Abstract

Turnover of focal adhesions allows cell retraction, which is essential for cell migration. The mammalian spectraplakin protein, ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal adhesions. However, it remains unclear how the activity of ACF7 is regulated spatiotemporally to achieve focal adhesion-specific guidance of microtubule. To explore the potential mechanisms, we resolve the crystal structure of ACF7's NT (amino-terminal) domain, which mediates F-actin interactions. Structural analysis leads to identification of a key tyrosine residue at the calponin homology (CH) domain of ACF7, whose phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin binding of ACF7. Using skin epidermis as a model system, we further demonstrate that the phosphorylation of ACF7 plays an indispensable role in focal adhesion dynamics and epidermal migration in vitro and in vivo. Altogether, our findings provide critical insights into the molecular mechanisms underlying coordinated cytoskeletal dynamics during cell movement.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [3];  [2];  [2];  [1]
+ Show Author Affiliations
  1. The Univ. of Chicago, Chicago, IL (United States)
  2. Guanxi Normal Univ., Guilin (China)
  3. Univ. of Louisville, Louisville, KY (United States)
Publication Date:
Research Org.:
Univ. of Chicago, IL (United States). Ben May Dept. for Cancer Research
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER); National Cancer Institute (NCI); University of Chicago; National Institutes of Health (NIH); American Cancer Society; V foundation; Natural Science Foundation of China; Natural Science Foundation of Guangxi
OSTI Identifier:
1261624
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 7; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; induced-fit mechanism; actin-binding domain; f-actin; alpha-actinin; microtubule dynamics; cell-migration; kinase; src; promotes; phosphorylation

Citation Formats

Yue, Jiping, Zhang, Yao, Liang, Wenguang G., Gou, Xuewen, Lee, Philbert, Liu, Han, Lyu, Wanqing, Tang, Wei -Jen, Chen, Shao -Yu, Yang, Feng, Liang, Hong, and Wu, Xiaoyang. In vivo epidermal migration requires focal adhesion targeting of ACF7. United States: N. p., 2016. Web. doi:10.1038/ncomms11692.
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Yue, Jiping, Zhang, Yao, Liang, Wenguang G., Gou, Xuewen, Lee, Philbert, Liu, Han, Lyu, Wanqing, Tang, Wei -Jen, Chen, Shao -Yu, Yang, Feng, Liang, Hong, & Wu, Xiaoyang. In vivo epidermal migration requires focal adhesion targeting of ACF7. United States. https://doi.org/10.1038/ncomms11692
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Yue, Jiping, Zhang, Yao, Liang, Wenguang G., Gou, Xuewen, Lee, Philbert, Liu, Han, Lyu, Wanqing, Tang, Wei -Jen, Chen, Shao -Yu, Yang, Feng, Liang, Hong, and Wu, Xiaoyang. Tue . "In vivo epidermal migration requires focal adhesion targeting of ACF7". United States. https://doi.org/10.1038/ncomms11692. https://www.osti.gov/servlets/purl/1261624.
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@article{osti_1261624,
title = {In vivo epidermal migration requires focal adhesion targeting of ACF7},
author = {Yue, Jiping and Zhang, Yao and Liang, Wenguang G. and Gou, Xuewen and Lee, Philbert and Liu, Han and Lyu, Wanqing and Tang, Wei -Jen and Chen, Shao -Yu and Yang, Feng and Liang, Hong and Wu, Xiaoyang},
abstractNote = {Turnover of focal adhesions allows cell retraction, which is essential for cell migration. The mammalian spectraplakin protein, ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal adhesions. However, it remains unclear how the activity of ACF7 is regulated spatiotemporally to achieve focal adhesion-specific guidance of microtubule. To explore the potential mechanisms, we resolve the crystal structure of ACF7's NT (amino-terminal) domain, which mediates F-actin interactions. Structural analysis leads to identification of a key tyrosine residue at the calponin homology (CH) domain of ACF7, whose phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin binding of ACF7. Using skin epidermis as a model system, we further demonstrate that the phosphorylation of ACF7 plays an indispensable role in focal adhesion dynamics and epidermal migration in vitro and in vivo. Altogether, our findings provide critical insights into the molecular mechanisms underlying coordinated cytoskeletal dynamics during cell movement.},
doi = {10.1038/ncomms11692},
journal = {Nature Communications},
number = ,
volume = 7,
place = {United States},
year = {Tue May 24 00:00:00 EDT 2016},
month = {Tue May 24 00:00:00 EDT 2016}
}
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https://doi.org/10.1038/ncomms11692
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Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo
journal, February 2011

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